Formula

Da Chai Hu Tang

Major Bupleurum Decoction | 大柴胡汤

Key Ingredients

Chai Hu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to address conditions where illness has affected both the body's surface and its interior, particularly when Heat has begun to accumulate in the digestive system. It is commonly applied for upper abdominal pain and fullness, nausea and vomiting, alternating chills and fever, constipation, and irritability. Modern practitioners frequently use it for gallbladder and pancreatic conditions.

Formula Category

Main Actions

  • Harmonizes the Shaoyang
  • Clears Interior Heat
  • Clears Gallbladder and Stomach Heat
  • Directs Rebellious Qi Downward and Stops Vomiting
  • Moves Qi and Resolves Stagnation
  • Eliminates Focal Distention and Fullness

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Da Chai Hu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Da Chai Hu Tang addresses this pattern

This is the primary pattern for Da Chai Hu Tang. A pathogenic Heat that originally entered through the body's exterior has become trapped in the Shaoyang (Lesser Yang) level while simultaneously beginning to accumulate in the Yangming (Bright Yang) level. The Shaoyang component manifests as alternating chills and fever, fullness and discomfort in the chest and rib area, and irritability. The Yangming component shows as epigastric hardness and pain, constipation (or burning diarrhea), a yellow tongue coating, and a wiry, forceful pulse. The formula addresses both levels simultaneously: Chai Hu and Huang Qin harmonize and clear the Shaoyang, while Da Huang and Zhi Shi gently purge the Yangming accumulation. Shao Yao relieves the abdominal pain that bridges both levels, and Ban Xia with Sheng Jiang controls the vomiting caused by the obstruction of Qi in the middle. The Shaoyang component remains the primary focus, with the purgative action being moderate rather than aggressive.

A practitioner would look for one or more of these signs

Chills

Classic Shaoyang sign, indicating the pathogen is caught between exterior and interior

Chest And Hypochondrium Fullness

Fullness and distention in the chest and rib sides, worse on pressure

Nausea Or Vomiting

Persistent, forceful vomiting that does not stop, more severe than in ordinary Shaoyang patterns

Epigastric Pain Relieved With Pressure Or Eating

Hard fullness or distending pain below the heart area, tender on pressure

Constipation

Difficulty with bowel movements due to interior Heat accumulation, or alternately burning diarrhea

Irritability

A feeling of pent-up frustration and restlessness (郁郁微烦)

How It Addresses the Root Cause

Da Chai Hu Tang addresses a condition where a pathogenic influence has become lodged between two layers of the body at once. In TCM terms, the Shaoyang (the "hinge" level, governed by the Gallbladder) is still unresolved, while Heat has also begun to accumulate in the Yangming (the Stomach and intestines). This is called a Shaoyang-Yangming combined disease (少阳阳明合病).

At the Shaoyang level, the body's defensive mechanism is locked in a stalemate with the pathogen, unable to fully expel it outward or contain it inward. This produces the hallmark alternating chills and fever, a sense of fullness and discomfort along the ribs and flanks, and irritability. Meanwhile, Heat that has spilled into the Yangming level begins to congeal in the upper digestive tract, creating a kind of "thermal blockage" in the stomach and intestines. This blockage drives Stomach Qi upward instead of downward, causing persistent vomiting and nausea, while also producing a hard, painful feeling below the ribcage (the area TCM calls "below the heart"). In some cases, the trapped Heat forces fluids downward inappropriately, producing foul-smelling diarrhoea rather than constipation, a phenomenon classical texts call "concurrent Heat diarrhoea" (协热下利).

The key diagnostic insight is that neither Shaoyang harmonising alone (as with Xiao Chai Hu Tang) nor Yangming purging alone (as with the Cheng Qi formulas) would suffice. The Shaoyang blockage prevents the normal outward resolution of the pathogen, while the Yangming Heat accumulation demands some degree of downward drainage. Da Chai Hu Tang resolves both simultaneously: releasing the Shaoyang pivot so Qi can flow freely again, while gently clearing the interior Heat so the digestive system can resume its normal descending function.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly bitter and pungent, with a sour undertone from Shao Yao and mild sweetness from Da Zao. The bitter flavour drains Heat and dries Dampness, the pungent flavour disperses stagnation, and the sour flavour restrains and softens, together creating a formula that clears, moves, and harmonises.

Target Organs
Liver Gallbladder Stomach Large Intestine Spleen
Channels Entered
Gallbladder Liver Stomach Large Intestine Spleen

Formula Origin

Shāng Hán Lùn (Treatise on Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Da Chai Hu Tang

Detailed information about each herb in Da Chai Hu Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum root

Dosage: 12 - 24g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Da Chai Hu Tang

The chief herb used in large dosage, Chai Hu resolves the Shaoyang (Lesser Yang) stage disorder by dispersing constrained Heat from the half-exterior half-interior level. It courses Liver Qi, resolves knotted Qi in the chest and flanks, and drives out pathogenic factors from the Shaoyang pivot.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Da Chai Hu Tang

Bitter and cold, Huang Qin clears Heat from the Gallbladder and Stomach, complementing Chai Hu to form the core herb pair for harmonizing the Shaoyang. While Chai Hu lifts and disperses, Huang Qin descends and purges Heat, preventing the pathogen from penetrating deeper.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 3 - 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Da Chai Hu Tang

Used at a relatively modest dose, Da Huang purges Heat accumulation from the Yangming (Bright Yang) channel, opens the bowels, and promotes bile flow. Combined with Zhi Shi, it forms the core of the purgative action that distinguishes this formula from Xiao Chai Hu Tang. Its light dosage reflects that the interior Heat has not yet become severe.

Zhi Shi
Zhi Shi

Immature Bitter Orange Fruit

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Da Chai Hu Tang

Breaks up stagnant Qi and disperses focal distention and accumulation in the epigastrium. Together with Da Huang, it forms a small Cheng Qi Tang (Regulate the Qi Decoction) structure within the formula, addressing the Yangming Heat and fullness. With Chai Hu and Shao Yao, it echoes the Si Ni San structure for coursing Liver Qi.

Bai Shao
Bai Shao

White peony root

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Da Chai Hu Tang

Softens the Liver, nourishes Blood, and relieves cramping abdominal pain. Combined with Da Huang, it treats substantial pain in the abdomen. Combined with Zhi Shi, it regulates the interplay of Qi and Blood to resolve the hard fullness and pain below the heart. Its sour, collecting nature also moderates the strongly dispersing actions of the other herbs.

Ban Xia
Ban Xia

Pinellia rhizome

Dosage: 6 - 12g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Da Chai Hu Tang

Descends rebellious Stomach Qi, harmonizes the Stomach, and stops the persistent vomiting that is a hallmark of this pattern. Combined with the large dose of Sheng Jiang, it forms a Xiao Ban Xia Tang (Minor Pinellia Decoction) structure that powerfully controls nausea and vomiting.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 9 - 15g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Da Chai Hu Tang

Used in an unusually large dose in this formula, Sheng Jiang assists Ban Xia in descending Stomach Qi and stopping vomiting. It also disperses accumulation with its warm, acrid nature and helps harmonize the Stomach. Together with Da Zao, it regulates the Nutritive and Defensive Qi and harmonizes all the herbs.

Da Zao
Da Zao

Jujube fruit

Dosage: 4 - 6 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Da Chai Hu Tang

Strengthens the Spleen and Stomach, generates fluids, and moderates the harsh or attacking actions of the other herbs. Paired with Sheng Jiang, it harmonizes the Nutritive and Defensive Qi and ensures the formula does not damage the Stomach while purging.

Modern Research (4 studies)

  • Randomized active-controlled clinical trial: Efficacy and safety of Da-Chai-Hu-Tang on lipid profiles in statin-treated patients with residual hypertriglyceridaemia (2022)
  • Animal study: Da-Chai-Hu-Tang protects from acute intrahepatic cholestasis via PPARα activation (2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes to 1 hour after meals, warm, divided into 2-3 doses per day. Taking after meals reduces the risk of stomach irritation from Da Huang and Zhi Shi.

Typical Duration

Acute use: 3-7 days for febrile illness or acute biliary/pancreatic episodes; may extend to 2-4 weeks for subacute conditions, with reassessment by a practitioner.

Dietary Advice

While taking this formula, avoid greasy, fried, and fatty foods, as these burden the Stomach and Gallbladder and directly worsen the Heat accumulation the formula is trying to clear. Also avoid alcohol, spicy foods, and rich meats, which generate internal Heat. Cold and raw foods should be limited as they can impair the Stomach's digestive function and interfere with the formula's action. Light, easily digestible foods are preferred: congee (rice porridge), steamed vegetables, lightly cooked grains, and clear soups. If constipation is part of the presentation, mildly fibre-rich foods such as cooked leafy greens may be supportive. Avoid overeating: smaller, more frequent meals help the compromised Stomach-Gallbladder axis recover.

Modern Usage

Da Chai Hu Tang is classified as a formula for releasing both the Exterior and Interior. It has the effects of harmonizing the Shao Yang Stage (according to the 6 Stage Theory of Zhang Zhong Jing) and purging internal Heat accumulation. It is primarily used to treat combined Shao Yang and Yang Ming Stage disorders.
Symptoms include alternating chills and fever, fullness and discomfort in the chest and hypochondrium, persistent vomiting, slight irritability, hardness and fullness below the heart (epigastric region), or fullness and pain below the heart, constipation, or diarrhea with heat, a yellow tongue coating, and a wiry, rapid, and forceful pulse.
Clinically, this formula is often used to treat conditions such as acute pancreatitis, acute cholecystitis, cholelithiasis (gallstones), and gastric and duodenal ulcers that present with combined Shao Yang and Yang Ming stage patterns.

Special Populations

Pregnancy

Contraindicated during pregnancy. Da Huang (rhubarb root, 大黄) is a strong purgative that stimulates intestinal peristalsis and can reflexively stimulate uterine contractions, posing a risk of miscarriage. Zhi Shi (immature bitter orange, 枳实) has a powerful downward-directing and Qi-breaking action that is also traditionally cautioned against in pregnancy. Together, these two herbs make this formula unsuitable for pregnant women. If a pregnant patient presents with a Shaoyang-Yangming pattern, the formula must be substantially modified or replaced under close practitioner supervision.

Breastfeeding

Use with caution during breastfeeding. Da Huang (rhubarb) contains anthraquinone compounds that can transfer into breast milk and may cause loose stools or diarrhoea in the nursing infant. Ban Xia (pinellia) is mildly toxic in unprocessed form, though the formula calls for processed Ban Xia. If this formula is clinically necessary for the mother, the infant should be monitored for digestive disturbance, and the treatment duration should be kept as short as possible. Consult a qualified practitioner before use while breastfeeding.

Pediatric Use

Da Chai Hu Tang may be used in children when the pattern clearly matches (Shaoyang-Yangming combined disease), but with significant dosage reduction. As a general guide, children aged 6-12 may receive one-third to one-half of the adult dose, and children over 12 may receive one-half to two-thirds. It is generally not recommended for children under 6 without specialist supervision. The Da Huang (rhubarb) dose in particular must be carefully reduced, as children are more sensitive to purgative effects and can quickly develop diarrhoea or fluid loss. The treatment course should be kept short (typically 3-5 days for acute conditions) and the child monitored for signs of excessive purging such as watery stools, abdominal cramping, or fatigue. Always consult a qualified TCM paediatric practitioner.

Drug Interactions

Anticoagulants and antiplatelet agents (warfarin, heparin, aspirin, clopidogrel): Da Huang (rhubarb) has blood-activating and purgative properties. Its anthraquinone compounds may potentiate anticoagulant effects, increasing the risk of bleeding. Patients on blood-thinning medications should have their INR or coagulation parameters monitored closely.

Cardiac glycosides (digoxin): Da Huang's purgative action may cause potassium loss through diarrhoea, potentially increasing sensitivity to digoxin toxicity. Electrolyte levels should be monitored.

Antihypertensive medications: The formula's overall cooling and draining properties may have additive blood-pressure-lowering effects. Patients on antihypertensives should monitor for symptoms of hypotension.

Statin medications: While one clinical trial showed safe co-administration with statins for triglyceride reduction, the combination should still be monitored by both the prescribing physician and TCM practitioner, as both statins and Da Huang are metabolised hepatically and could theoretically compete for liver enzyme pathways.

Cytochrome P450 substrates: Huang Qin (Scutellaria) contains baicalin and baicalein, which have been shown to interact with CYP450 enzymes (particularly CYP3A4 and CYP1A2). Medications with narrow therapeutic windows that are metabolised by these enzymes (such as cyclosporine, certain anti-epileptics, or some benzodiazepines) should be used with caution alongside this formula.

Contraindications

Avoid

Spleen and Stomach deficiency Cold patterns (chronic cold abdomen, loose stools, cold limbs) without any signs of Heat or excess. Da Huang and Zhi Shi in this formula can severely damage already weakened digestive function.

Avoid

Pregnancy. The formula contains Da Huang (rhubarb), which stimulates intestinal peristalsis and may promote uterine contractions, and Zhi Shi (immature bitter orange), which has strong Qi-descending action. Both pose risk to the fetus.

Avoid

Pure Shaoyang pattern without Yangming involvement. If there is no interior Heat or accumulation (no constipation, epigastric hardness, or yellow tongue coating), Xiao Chai Hu Tang is more appropriate. Using Da Chai Hu Tang would needlessly purge.

Caution

Severe Yin or Blood deficiency with dry stools. In patients where constipation results from fluid depletion rather than Heat excess, the purgative action of Da Huang can further damage Yin and fluids.

Caution

Elderly or constitutionally weak patients. The formula's combined dispersing and purging actions can be too aggressive. Dosages should be reduced and the patient monitored closely.

Caution

Patients currently experiencing heavy menstrual bleeding or other active hemorrhage. Da Huang activates Blood movement and could worsen bleeding.

Caution

Concurrent use of anticoagulant or antiplatelet medications. Da Huang has blood-activating properties that may potentiate bleeding risk.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

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Manufacturing, supplier, and product specifications

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