Formula

Chai Hu Shu Gan Tang

Bupleurum Spreading Decoction | 柴胡疏肝散

Also known as:

Bupleurum Powder to Dredge the Liver , Bupleurum Spreading the Liver Decoction , Bupleurum Spread the Liver Decoction

Properties

Qi-regulating formulas · Slightly Warm

Key Ingredients

Chai Hu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for people experiencing rib-side or chest pain, emotional frustration, irritability, sighing, and bloating caused by stagnation of Liver Qi. It works by smoothing the flow of Liver Qi, relieving tension, and gently moving blood to stop pain. It is one of the most widely used formulas for stress-related digestive and emotional complaints.

Formula Category

Main Actions

  • Courses the Liver and Resolves Constraint
  • Moves Qi and Alleviates Pain
  • Invigorates Blood and Dispels Stasis
  • Harmonizes the Liver and Spleen

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chai Hu Shu Gan San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Chai Hu Shu Gan San addresses this pattern

This is the primary pattern addressed by the formula. When emotional frustration or stress causes the Liver to lose its natural ability to spread and regulate Qi, the result is Liver Qi stagnation. The Liver channel traverses the rib sides, so when its Qi stops flowing, pain and distension occur along the flanks and chest. The stagnant Qi also disrupts mood, causing irritability, depression, and frequent sighing (as the body attempts to physically move stuck Qi). The formula directly restores the Liver's spreading function: Chai Hu, Xiang Fu, and Chuan Xiong powerfully free the constrained Qi, while Bai Shao nourishes the Liver to prevent the dispersal from going too far. This is the classical "orthodox method for coursing the Liver" (疏肝的正法).

A practitioner would look for one or more of these signs

Hypochondriac Pain

Distending or pulling pain along the ribs, often worsened by emotional upset

Feeling Of Chest Oppression

A feeling of tightness or stuffiness in the chest

Irritability

Easily angered or emotionally volatile

Depression

Emotional low mood, feelings of constraint and frustration

Frequent Bleeding

Frequent deep sighing as the body tries to relieve stuck Qi

Abdominal Distention

Bloating and fullness in the upper abdomen

Belching

Frequent belching from Liver Qi invading the Stomach

How It Addresses the Root Cause

The Liver in TCM is responsible for the smooth, unobstructed flow of Qi throughout the body. It thrives on free movement and is easily disrupted by emotional frustration, anger, or prolonged stress. When emotions are not expressed or resolved, the Liver's ability to "spread" Qi becomes impaired, a condition called Liver Qi stagnation (肝气郁结). This is the core pathology that Chai Hu Shu Gan San addresses.

When Liver Qi stagnates, the flow through the Liver's channel pathway, which runs along the flanks and ribs, becomes obstructed. This directly produces the hallmark symptom of pain or distension in the hypochondriac region (the sides of the torso beneath the ribs). Because the Qi cannot move freely, patients often feel a heavy, tight sensation in the chest, sigh frequently (the body's instinctive attempt to release pent-up Qi), and become emotionally irritable or depressed. The stagnant Qi can also rebel sideways and invade the Stomach and Spleen, disrupting digestion and causing bloating, belching, poor appetite, or nausea. Over time, stagnant Qi inevitably leads to Blood stasis, since Qi is the motive force that drives Blood circulation. This secondary Blood stasis intensifies and fixes the pain.

The classical principle at work here is "wood constraint should be unbound" (木郁达之), from the Nei Jing tradition. The Liver belongs to Wood, and when Wood is constrained, the treatment is to release it, to restore the natural spreading, ascending quality of Liver Qi. Chai Hu Shu Gan San does precisely this: it unblocks stagnant Liver Qi, gently moves the accompanying Blood stasis, and restores harmony between the Liver and its most vulnerable neighbour, the Spleen-Stomach system.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter with mild sweetness. The acrid quality disperses stagnation and moves Qi, the bitter quality directs downward and resolves constraint, and the sweet quality harmonizes and moderates the formula's drying nature.

Target Organs
Liver Spleen Stomach Gallbladder
Channels Entered
Liver Gallbladder Stomach Spleen

Formula Origin

Jǐng Yuè Quán Shū (景岳全书, Jingyue's Complete Works) by Zhang Jingyue, citing Yi Xue Tong Zhi (医学统旨)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Chai Hu Shu Gan Tang

Detailed information about each herb in Chai Hu Shu Gan Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum root

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Chai Hu Shu Gan Tang

The chief herb of the formula. Chai Hu excels at coursing the Liver and resolving stagnation. Used at the highest dose, it directly addresses the core problem of Liver Qi constraint by lifting and spreading the depressed Qi of the Liver channel.

Xiang Fu
Xiang Fu

Nutgrass Galingale Rhizome

Dosage: 4.5 - 6g

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Parts Used Rhizome (根茎 gēn jīng)
Role in Chai Hu Shu Gan Tang

Enters the Liver channel directly to regulate Qi, relieve constraint, and stop pain. It reinforces Chai Hu's ability to free stagnant Liver Qi while adding a stronger pain-relieving action, particularly for distending pain in the chest and flanks.

Chuan Xiong
Chuan Xiong

Sichuan lovage rhizome

Dosage: 4.5 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Chai Hu Shu Gan Tang

Known as the 'Qi herb within the Blood,' Chuan Xiong moves blood and promotes the circulation of Qi simultaneously. It assists Chai Hu in resolving Liver stagnation while addressing the blood stasis that inevitably accompanies prolonged Qi constraint, thereby relieving pain.

Chen Pi
Chen Pi

Tangerine peel

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen
Parts Used Peel / Rind (皮 pí / 果皮 guǒ pí)
Role in Chai Hu Shu Gan Tang

Regulates Qi, harmonizes the Stomach, and resolves stagnation in the Middle Burner. When Liver Qi invades the Stomach, digestive symptoms like bloating and belching arise. Chen Pi addresses this secondary mechanism and supports healthy digestion. Vinegar-processed (醋炒) to enhance its Liver-entering action.

Zhi Ke
Zhi Ke

Bitter orange fruit

Dosage: 4.5 - 6g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine, Lungs
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Chai Hu Shu Gan Tang

Moves Qi, widens the chest, and reduces abdominal distension. Works together with Chen Pi to regulate the Qi mechanism in the Middle Burner, alleviating the fullness and bloating caused by stagnant Liver Qi overacting on the digestive system.

Bai Shao
Bai Shao

White peony root

Dosage: 4.5 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Chai Hu Shu Gan Tang

Nourishes Liver blood and softens the Liver, moderating the drying and dispersing nature of the other Qi-moving herbs. Paired with Zhi Gan Cao, it relaxes spasm and eases pain (the classical Shao Yao Gan Cao Tang pairing within this formula). Provides the essential 'restraining' balance to prevent excessive Qi dispersion from injuring Liver Yin.

Gan Cao
Gan Cao

Licorice root

Dosage: 1.5 - 3g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Chai Hu Shu Gan Tang

Harmonizes all the herbs in the formula. Together with Bai Shao, it relaxes tension and stops pain. Used at the lowest dose, it also mildly tonifies the Spleen to support the Middle Burner and prevent the strong Qi-moving herbs from weakening digestion.

Modern Research (4 studies)

  • Systematic review and meta-analysis of 42 RCTs on Chai Hu Shu Gan San for depression (2018)
  • Updated systematic review and meta-analysis of Chaihu-Shugan-San for depression with Mendelian randomization (2024)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes before meals, morning and evening (the classical text specifies taking on an empty stomach to facilitate Qi-moving action).

Typical Duration

Acute Liver Qi stagnation episodes: 1-2 weeks. Chronic conditions (depression, digestive disorders, menstrual irregularity): 4-8 weeks with periodic reassessment, as long-term use of this acrid, drying formula can deplete Qi and Yin.

Dietary Advice

While taking this formula, it is advisable to avoid foods and drinks that can worsen Liver Qi stagnation or generate internal Heat. This includes alcohol, greasy or deep-fried foods, excessively spicy foods, and strong coffee. Emotionally-driven overeating should also be avoided. Favor light, easily digestible meals with plenty of lightly cooked vegetables. Foods traditionally considered beneficial for the Liver's smooth flow include leafy greens, celery, sprouted grains, and citrus peel (in moderation). Sour foods in small amounts (such as a little vinegar or lemon) can support the Liver, but excessive sour intake can over-contract Liver Qi and work against the formula's dispersing action. Eating at regular times and in a relaxed setting supports the Liver-Spleen harmony the formula seeks to restore.

Modern Usage

This formula is commonly used for soothing the Liver and relieving depression. Clinically, it is often used for chronic hepatitis, chronic gastritis, cholecystitis, and intercostal neuralgia that fall under the category of liver qi stagnation.

Special Populations

Pregnancy

Use with caution during pregnancy. This formula contains Chuan Xiong (Ligusticum chuanxiong), which is a well-known Blood-invigorating herb that can increase pelvic circulation, and Xiang Fu (Cyperus rotundus), a strong Qi-moving herb. Both of these actions could theoretically promote uterine contractions or disturb fetal stability. Zhi Ke (Fructus Aurantii, bitter orange) also has downward-directing Qi movement that is traditionally cautioned during pregnancy. While none of these herbs are as strongly abortifacient as herbs like San Leng or E Zhu, the overall Qi-moving and Blood-activating character of the formula means it should generally be avoided unless specifically prescribed and monitored by an experienced practitioner who deems the benefit outweighs the risk.

Breastfeeding

There is limited specific safety data on Chai Hu Shu Gan San during breastfeeding. The herbs in this formula are generally mild and do not contain known toxic components that pose clear risks of transfer through breast milk. Notably, the formula has actually been used traditionally (with modifications) to treat lactation insufficiency caused by Liver Qi stagnation, as free flow of Liver Qi is considered important for smooth milk let-down. However, the acrid, Qi-moving nature of the formula means it should be used judiciously and not taken long-term without professional supervision. It is prudent to consult a qualified practitioner before use while breastfeeding.

Pediatric Use

Chai Hu Shu Gan San can be used in children, but with significant dosage reduction proportional to age and body weight. A general guideline: children aged 6-12 may take roughly one-third to one-half the adult dose, while children under 6 should take one-quarter or less. The formula's acrid, Qi-moving nature means it should be used cautiously in very young children whose digestive systems are still developing and whose Qi and Yin are not yet fully established. It is best suited for older children and adolescents who present with clear signs of Liver Qi stagnation, such as emotional frustration, sighing, and flank discomfort. Use should be short-term and supervised by a qualified practitioner. Not generally recommended for infants.

Drug Interactions

Gan Cao (Licorice root): Glycyrrhizin in licorice can cause pseudoaldosteronism (sodium retention, potassium loss, and elevated blood pressure). It may interact with antihypertensive medications (reducing their effectiveness), diuretics (particularly potassium-depleting diuretics like furosemide, increasing hypokalemia risk), corticosteroids (potentiating their effects), and cardiac glycosides such as digoxin (hypokalemia from licorice increases sensitivity to digoxin toxicity). Though the dose of Gan Cao in this formula is small (1.5g), awareness is warranted.

Chuan Xiong (Ligusticum chuanxiong): This herb has documented antiplatelet and blood-activating properties. It may potentiate the effects of anticoagulant drugs (warfarin, heparin) and antiplatelet agents (aspirin, clopidogrel), potentially increasing bleeding risk. Patients scheduled for surgery should discontinue use at least 1-2 weeks prior.

Chai Hu (Bupleurum): Bupleurum saponins may affect hepatic cytochrome P450 enzyme activity, potentially altering the metabolism of drugs processed through the liver. Caution is advised when combining with drugs with narrow therapeutic windows that are CYP-metabolized. Additionally, given that the formula is frequently used alongside antidepressants in clinical practice, practitioners should monitor for potential serotonergic interactions when combining with SSRIs or SNRIs, although no severe interactions have been reported in the meta-analyses reviewed.

Contraindications

Avoid

Liver Qi stagnation pain caused by underlying Qi deficiency or Yin deficiency. This formula is aromatic, acrid, and drying in nature, meaning it can further consume Qi and Yin. Patients who are fundamentally weak or depleted should not use it without significant modification.

Avoid

Liver Yang rising or Liver Fire flaring. When stagnation has already transformed into blazing Heat, with symptoms like severe headaches, red face and eyes, a bitter taste in the mouth, and a rapid wiry pulse, this predominantly Qi-moving formula is insufficient and may aggravate the upward flaring.

Avoid

Damp-Heat accumulation in the Liver and Gallbladder (such as jaundice with bitter taste, greasy yellow tongue coating). The warm, drying, Qi-moving herbs in this formula are not suited to clear Damp-Heat and may worsen it.

Caution

Pregnancy. The formula contains Chuan Xiong (Ligusticum) and Xiang Fu (Cyperus), which have significant Blood-moving and Qi-moving actions that could potentially stimulate uterine activity.

Caution

Long-term continuous use. Because the formula is composed largely of acrid, aromatic, Qi-moving herbs, prolonged use without reassessment may injure Qi and Yin over time.

Caution

Patients on anticoagulant or antiplatelet medications should use with caution due to the Blood-moving properties of Chuan Xiong (Ligusticum).

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with Qi or Yin Deficiency should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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