Formula

Chai Ge Jie Ji Tang

Bupleurum & Pueraria Combination | 柴葛解肌汤

Also known as:

Bupleurum and Kudzu Decoction to Release the Muscle Layer

Properties

Exterior-releasing formulas · Slightly Cool

Key Ingredients

Chai Hu, Ge Gen

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for the early stage of a cold or flu where initial chills are fading but fever is rising, accompanied by headache, eye pain, nasal dryness, and restless sleep. It works by gently opening the body's surface to release the trapped pathogen while simultaneously clearing the internal heat that has begun to build up.

Formula Category

Main Actions

  • Releases the Muscle Layer
  • Clears Interior Heat
  • Disperses Wind-Cold from the Exterior
  • Relieves Headaches
  • Harmonizes the Three Yang Channels

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chai Ge Jie Ji Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Chai Ge Jie Ji Tang addresses this pattern

This is the primary pattern for Chai Ge Jie Ji Tang. The condition begins as an exterior Wind-Cold invasion, but because the pathogen is not resolved promptly, it becomes trapped and transforms into heat. The patient is caught between two stages: some exterior Cold symptoms remain (chills, body aches, absence of sweating) while interior Heat symptoms are emerging (rising fever, dry nose and throat, eye pain, irritability, insomnia). The tongue coating shifts from white to thin yellow, and the pulse becomes floating but with a slightly surging (hong) quality.

Chai Hu and Ge Gen release the lingering pathogen from the muscle layer. Qiang Huo and Bai Zhi scatter residual Wind-Cold and relieve head and body pain. Shi Gao and Huang Qin clear the interior heat before it intensifies further. Bai Shao protects the Ying level from being damaged by the heat, and Jie Geng opens the Lung to facilitate the outward movement of the pathogen. The formula is ideally timed for this transitional window when both cold and heat coexist.

A practitioner would look for one or more of these signs

Fever

Increasing fever with decreasing chills

Headaches

Headache, especially frontal or orbital

Eye Pain

Pain around the eye sockets

Vaginal Dryness

Dry nasal passages

Insomnia

Restless sleep or inability to sleep due to heat disturbing the spirit

Dry Throat

Dry or sore throat

Body Aches

Generalized body aches and limb soreness

Absence of Sweating

No sweating despite rising fever

How It Addresses the Root Cause

This formula addresses a specific transitional stage of an externally-contracted illness. A person catches a common cold from Wind-Cold, but the body's struggle against the pathogen generates Heat, causing the illness to partially shift inward. The result is a condition that straddles two or three of the body's Yang channel systems simultaneously.

Initially, the Wind-Cold lodges in the Tai Yang (Bladder) layer, producing chills, headache, and an absence of sweating. As the trapped pathogen generates Heat, it begins to affect the Yang Ming (Stomach) channel, which runs through the face, along the nose, and around the eye sockets. This is why symptoms like orbital pain, dry nose, and dry throat appear. The Shao Yang (Gallbladder) channel, which passes around the ears and sides of the head, may also be affected, producing earache or muffled hearing. When this interior Heat disturbs the spirit (Shen), restlessness and insomnia follow.

The key diagnostic picture is a shift from predominantly cold symptoms to predominantly hot ones: chills are fading while fever is rising, the tongue coating has turned from white to thin yellow, and the pulse has become floating with a slightly surging quality. This is not yet a full-blown interior Heat condition (like the pattern treated by Bai Hu Tang), but it is no longer a simple exterior Cold. The illness sits at a critical juncture where pathogenic Cold on the surface and emerging Heat inside must both be addressed at the same time.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly acrid and bitter with mild sweetness — acrid to open the exterior and disperse pathogens, bitter to clear Heat, and sweet to harmonize and protect the Stomach.

Target Organs
Lungs Stomach Gallbladder
Channels Entered
Lung Stomach Gallbladder Bladder

Formula Origin

Shāng Hán Liù Shū (伤寒六书, Six Books on Cold Damage) by Táo Huá (陶华)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Chai Ge Jie Ji Tang

Detailed information about each herb in Chai Ge Jie Ji Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum root

Dosage: 6 - 12g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Releases pathogens from the muscle layer with its cool, acrid nature, ventilates and lifts constrained Yang Qi, and addresses the Shaoyang (Lesser Yang) aspect of the condition where heat has begun to penetrate inward.

Ge Gen
Ge Gen

Kudzu root

Dosage: 9 - 12g

Temperature Cool
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Releases the muscle layer and clears Yangming (Bright Yang) channel heat, generates fluids to counter the drying effect of heat, and relieves neck and upper back stiffness. Together with Chai Hu it forms the core pair targeting the transition zone between exterior and interior.

Shi Gao
Shi Gao

Gypsum

Dosage: 3 - 12g

Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Parts Used Mineral (矿物 kuàng wù)
Role in Chai Ge Jie Ji Tang

Clears heat from the Yangming (Stomach) channel. Its dosage is kept modest because the heat has only just begun entering this channel, not yet reaching the intensity that would require a full Bai Hu Tang approach.

Huang Qin
Huang Qin

Chinese skullcap root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Clears heat from the Shaoyang channel and the upper burner, particularly addressing Lung heat that manifests as irritability, dry throat, and insomnia. Pairs with Shi Gao to clear interior heat from two angles.

Qiang Huo
Qiang Huo

Notopterygium root and rhizome

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Urinary Bladder, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Chai Ge Jie Ji Tang

Disperses Wind-Cold from the Taiyang (Greater Yang) channel and alleviates headache and body aches. Enters the Taiyang and Yangming channels, supporting the King herbs in releasing the exterior pathogen.

Bai Zhi
Bai Zhi

Dahurian angelica root

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach, Large Intestine
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Disperses Wind-Cold and relieves frontal and orbital pain, which are characteristic Yangming channel symptoms. Works with Qiang Huo to scatter exterior pathogens while targeting the Yangming headache pattern.

Bai Shao
Bai Shao

White peony root

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Nourishes the Ying (Nutritive) level and softens the Liver to prevent the warm, dispersing herbs from consuming Yin and Blood. Helps moderate the acrid, dispersing nature of the formula to prevent excessive sweating.

Jie Geng
Jie Geng

Platycodon root

Dosage: 3 - 6g

Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Opens and diffuses Lung Qi, benefits the throat, and directs the actions of the other herbs upward to the chest and head where the symptoms are concentrated.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Chai Ge Jie Ji Tang

Harmonizes all the herbs in the formula, moderates the acrid and cold medicinals, and protects the Stomach Qi from the dispersing and clearing actions of the other ingredients.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 3 slices

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Chai Ge Jie Ji Tang

Regulates the Protective (Wei) and Nutritive (Ying) Qi to facilitate the release of pathogenic factors from the exterior. Also warms the Stomach to assist the cold and bitter herbs.

Da Zao
Da Zao

Chinese date (Jujube fruit)

Dosage: 2 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Chai Ge Jie Ji Tang

Tonifies the Spleen and Stomach, and together with Sheng Jiang harmonizes the Protective and Nutritive Qi layers to support the formula's exterior-releasing function.

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Take warm (温服), 2–3 times daily, ideally between meals or 30 minutes before meals. For acute high fever, the first dose may be taken immediately regardless of meal timing.

Typical Duration

Acute use: 1–5 days, discontinued once fever resolves and exterior symptoms clear.

Dietary Advice

Avoid cold and raw foods, iced drinks, and greasy or heavy meals while taking this formula, as these can hinder the body's ability to expel the exterior pathogen. Eat light, easily digestible foods such as rice porridge (congee), light soups, and steamed vegetables. Avoid alcohol and spicy foods, which can aggravate interior Heat. Stay well-hydrated with warm water or warm broth to support sweating and prevent fluid depletion. As a classical principle for exterior-releasing formulas, avoid wind exposure and keep warm after taking the decoction to support a gentle sweat.

Modern Usage

Chai Ge Jie Ji Tang is classified as a formula for relieving the Exterior, with functions that include dispersing Wind-Cold, relaxing the muscles, and clearing Heat. It is primarily used to treat conditions where an Exterior Wind-Cold invasion has transformed into Heat. Symptoms include a gradual reduction in chills, increasing fever, lack of sweating, headache, eye pain, dry nose, irritability, insomnia, dry throat, ear congestion, pain around the eye sockets, a thin yellow tongue coating, and a floating, slightly rapid pulse.

Clinically, this formula is commonly used to treat colds, influenza, gingivitis, and acute conjunctivitis, particularly when these conditions are due to an Exterior Wind-Cold that has transformed into Heat.

Special Populations

Pregnancy

Use with caution during pregnancy. Qiang Huo and Bai Zhi are acrid dispersing herbs that promote the outward movement of Qi and may potentially destabilize the fetus. Shi Gao (Gypsum) is very cold in nature. While none of the herbs in this formula are classified as strongly abortifacient, the overall dispersing and cooling nature of the formula warrants care. Pregnant women should only take this formula under the direct supervision of a qualified practitioner, and only for short-term acute illness.

Breastfeeding

Generally considered acceptable for short-term use during breastfeeding for acute illness. The formula's herbs are predominantly exterior-releasing and Heat-clearing, with no strongly toxic components. However, the acrid dispersing herbs and the cold nature of Shi Gao and Huang Qin could theoretically affect breast milk quality or reduce milk production through their diaphoretic and cooling actions. Gan Cao (Licorice) is present in a small dose and unlikely to cause concern. Use should be kept brief (a few days for the acute episode) and under practitioner guidance.

Pediatric Use

Chai Ge Jie Ji Tang has a well-known reputation in modern Chinese pediatric practice for treating high fevers in children due to externally-contracted illness (Wind-Cold transforming to Heat). Dosages should be reduced proportionally based on the child's age and weight, typically to one-third to one-half of the adult dose for school-age children, and one-quarter for toddlers. The four key herbs (Chai Hu, Ge Gen, Qiang Huo, Shi Gao) should be adjusted based on whether the child's presentation leans more toward exterior Cold (increase Chai Hu, Ge Gen, Qiang Huo) or interior Heat (increase Shi Gao). Generally suitable for children over 1 year old. For very young infants, consult a pediatric TCM specialist. As with all children's formulas, monitor closely for sweating and fluid loss, and discontinue once fever resolves.

Drug Interactions

Gan Cao (Licorice): Contains glycyrrhizin, which may interact with antihypertensive medications by promoting sodium retention and potassium loss. It may also potentiate the effects of corticosteroids and interact with digoxin and diuretics through its mineralocorticoid-like activity. The dose in this formula is small (3g), which reduces but does not eliminate this concern.

Ge Gen (Kudzu Root): Contains isoflavones (notably puerarin) that may have additive effects with antidiabetic medications and could theoretically influence blood sugar levels. It may also interact with anticoagulant or antiplatelet drugs due to mild blood-thinning properties.

Chai Hu (Bupleurum): Contains saikosaponins that are metabolized by liver cytochrome P450 enzymes. Theoretically, this could affect the metabolism of drugs processed through these pathways. Patients on medications for liver conditions should be monitored.

Huang Qin (Scutellaria): Contains baicalin, which has demonstrated interactions with cyclosporine and may enhance the effect of certain antibiotics. It may also affect the absorption of drugs taken concurrently due to its tannin content.

Contraindications

Avoid

Pure Tai Yang exterior pattern where the pathogen has not yet begun transforming into interior Heat. Using this formula prematurely may draw the pathogen deeper inward (引邪入里).

Avoid

Yang Ming organ-level (Fu) pattern with constipation and hard stool (阳明腑实证). This formula addresses the channel level, not the organ level, and lacks purgative herbs needed for that stage.

Caution

Yin deficiency with pronounced internal Heat and dry fluids. The dispersing and acrid herbs in this formula can further injure Yin and fluids.

Caution

Patients who are already sweating freely or have Qi deficiency. The exterior-releasing herbs may cause excessive sweating and further deplete Qi.

Caution

Pure Wind-Heat exterior pattern without any residual Wind-Cold component. In such cases, formulas like Yin Qiao San or Sang Ju Yin are more appropriate.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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