Herb Whole plant / Aerial parts (全草 quán cǎo)

Xian He Cao

Hairy Vein Agrimony · 仙鹤草

Agrimonia pilosa Ledeb. · Herba Agrimoniae

Also known as: Long Ya Cao (龙牙草), Tuo Li Cao (脱力草)

Images shown are for educational purposes only

Agrimony herb is one of the most versatile bleeding-control herbs in Chinese medicine, effective for nosebleeds, coughing blood, heavy periods, and bleeding from the digestive tract. Beyond stopping bleeding, it has a well-known folk reputation as 'Fatigue-Relieving Grass,' used to restore energy and strength after overwork or prolonged illness. Its neutral temperature means it is safe and adaptable for many different body types.

TCM Properties

Temperature

Neutral

Taste

Bitter (苦 kǔ), Astringent (涩 sè)

Channels entered

Lungs, Liver, Spleen

Parts used

Whole plant / Aerial parts (全草 quán cǎo)

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What This Herb Does

Every herb has a specific set of actions — here's what Xian He Cao does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xian He Cao is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xian He Cao performs to restore balance in the body:

How these actions work

'Astringes and stops bleeding' is Xian He Cao's primary action. Its astringent (涩 sè) taste gives it a natural contracting, tightening quality that helps stem the flow of blood. Because the herb's temperature is neutral (平 píng), it does not push toward either warmth or cold, making it remarkably versatile: it can be used for bleeding caused by Heat, Cold, excess, or deficiency anywhere in the body, including coughing blood, vomiting blood, nosebleeds, blood in the urine or stool, and abnormal uterine bleeding. For Heat-type bleeding it is paired with cooling Blood herbs; for Cold-type or deficiency bleeding it is paired with warming and Qi-tonifying herbs.

'Tonifies deficiency and strengthens the body' is why the folk name for this herb is 'Fatigue-Relieving Grass' (脱力草 tuō lì cǎo). Despite being classified as a hemostatic, Xian He Cao has a well-established ability to relieve deep exhaustion and restore physical strength, especially after overwork or prolonged illness. It is commonly paired with red dates (大枣 dà zǎo) and taken as a simple decoction for people who feel weak and fatigued yet still have a normal appetite. This dual nature of stopping bleeding while simultaneously supplementing the body's reserves makes it especially useful when bleeding has led to weakness.

'Stops dysentery' draws on the herb's astringent quality to firm up the intestines and check diarrhea. It is particularly suited for chronic or bloody dysentery, where both the astringent and the blood-stopping actions are needed simultaneously. 'Checks malaria' is a traditional indication: the powdered herb was taken before a malarial attack to interrupt the cycle of chills and fever. 'Resolves toxins and kills parasites' refers to the herb's use for skin sores, boils, and vaginal itching caused by Trichomonas, where it can be applied both internally and as a topical wash.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Xian He Cao is used to help correct these specific patterns.

Why Xian He Cao addresses this pattern

When Heat invades the Blood level, it drives blood out of the vessels, causing various bleeding symptoms such as nosebleeds, vomiting blood, or heavy menstrual flow. Xian He Cao's astringent nature directly counteracts the reckless movement of blood by drawing it back into the vessels and promoting hemostasis. Although Xian He Cao itself is neutral and does not cool Heat, its broad-spectrum hemostatic action makes it an essential supporting herb in Blood Heat bleeding. Practitioners pair it with cooling Blood herbs like Sheng Di Huang or Ce Bai Ye to address the Heat root while Xian He Cao handles the bleeding itself.

A practitioner would look for one or more of these signs

Nosebleeds

Recurrent or profuse nosebleeds

Vomiting Blood

Vomiting blood or coughing blood with bright red colour

Postmenstrual Bleeding

Heavy or prolonged menstrual bleeding

Dark Blood In Stool

Blood in stool, especially bright red

Commonly Used For

These are conditions where Xian He Cao is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Blood Heat Spleen Qi Deficiency

TCM Interpretation

Heavy menstrual bleeding (崩漏 bēng lòu) is understood in TCM as the result of blood leaving its proper pathways in the uterus. Two main mechanisms drive this: either Heat in the Blood agitates it outward (leading to sudden, heavy, bright-red flow), or the Spleen Qi becomes too weak to 'hold' the blood (leading to prolonged, pale, watery bleeding that drains energy). In many women, both factors overlap, with Heat damage over time weakening the Spleen. The Liver channel, which governs the storage and smooth flow of blood, is also closely involved. The Chong and Ren extraordinary vessels, which regulate menstruation, become destabilized in either scenario.

Why Xian He Cao Helps

Xian He Cao directly addresses heavy menstrual bleeding through its astringent hemostatic action, physically helping to contract blood vessels and promote clotting in the uterine lining. Because it enters the Liver channel, which governs blood storage, it works at the site most relevant to menstrual control. Its neutral temperature means it is equally useful whether the bleeding stems from Heat or from Cold-deficiency, and it will not worsen either condition. Importantly, its secondary tonifying action helps restore the Qi and strength that heavy bleeding depletes, preventing the vicious cycle where blood loss causes more weakness, which causes more bleeding. Practitioners commonly pair it with Ejiao (donkey-hide gelatin) for combined blood-nourishing and hemostatic effect, or with Yi Mu Cao for uterine-specific support.

Also commonly used for

Nosebleeds

All types, whether from Heat or deficiency

Vomiting Blood

Hematemesis from various causes

Dark Blood In Stool

Including hemorrhoidal and intestinal bleeding

Cough Of Blood

Hemoptysis from lung conditions

Blood In Urine

Hematuria

Dysentery

Bloody dysentery (赤白痢)

Chronic Diarrhea

Especially with underlying deficiency

Night Sweats

Spontaneous sweating and night sweats

Peptic Ulcer

Gastric ulcer with bleeding

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Neutral

Taste

Bitter (苦 kǔ), Astringent (涩 sè)

Channels Entered

Lungs Liver Spleen

Parts Used

Whole plant / Aerial parts (全草 quán cǎo)

Dosage & Preparation

These are general dosage guidelines for Xian He Cao — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

6-15g

Maximum dosage

Up to 60-100g in specific clinical situations (such as Meniere's syndrome or severe fatigue), used short-term under direct practitioner supervision. High doses above 30g require clinical monitoring.

Dosage notes

Standard dose of 6-15g is used for routine hemostatic (blood-stopping) purposes. For treating exhaustion and fatigue (tuo li lao shang), the traditional dosage is 30g decocted with 10 red dates. For chronic conditions such as thrombocytopenia or ulcerative colitis, experienced practitioners often use 30-50g. For vertigo or Meniere's syndrome, some practitioners use 60-100g as a single herb decoction. Large doses (above 30g) should only be used under professional guidance, as adverse reactions have occasionally been reported at very high dosages.

Preparation

No special decoction handling required. The herb is simply decocted in the standard manner. For fresh herb preparations (juice), the fresh plant can be mashed and the juice extracted with cold water, then mixed with sugar for immediate consumption (a traditional method for acute hemoptysis).

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Xian He Cao does

Processing method

The cut segments of Xian He Cao are placed into a red-hot iron wok and stir-fried over high heat (武火), turning them continuously until the surface is completely blackened. A small amount of cold water is then sprinkled on to extinguish any sparks, and the material is immediately removed and spread out to cool completely.

How it changes properties

Charring enhances the astringent, hemostatic action by concentrating the tannin content and adding a carbonized binding quality. The temperature remains neutral, and the bitter-astringent taste intensifies. The charred form focuses more narrowly on stopping bleeding and has less of the tonifying and anti-dysentery range of the raw herb.

When to use this form

Used when the primary clinical goal is maximum hemostatic effect, such as for acute or heavy bleeding episodes where rapid control of blood loss is needed. The raw form is preferred when the tonifying or anti-dysentery actions are also desired.

Common Herb Pairs

These ingredients are traditionally combined with Xian He Cao for enhanced therapeutic effect

Ma Bian Cao
Ma Bian Cao 1:1, typically Xian He Cao 15–30g : Han Lian Cao 15–30g

Xian He Cao astringes and stops bleeding through its contracting quality, while Han Lian Cao (Eclipta) cools the blood and nourishes Liver and Kidney Yin. Together they stop bleeding from both the 'container' side (astringing) and the 'content' side (cooling reckless blood movement), making them effective for a wider range of bleeding types than either herb alone.

When to use: Nosebleeds, coughing blood, or heavy periods where there are signs of both Yin deficiency and active bleeding. Particularly useful for Lung- or Liver-channel bleeding with underlying deficiency.

Da Zao
Da Zao Xian He Cao 30g : Da Zao 10 pieces (approximately 30g)

Xian He Cao provides astringent hemostatic and mild tonifying action, while Da Zao (red dates) tonifies Spleen Qi, nourishes blood, and harmonizes the formula. Together they form the classic folk remedy for exhaustion and fatigue, combining the 'Fatigue-Relieving Grass' with the Qi-and-Blood nourishing power of dates. The pairing also helps treat sweating disorders by firming the exterior through Qi supplementation.

When to use: Physical exhaustion from overwork (脱力劳伤), chronic fatigue with normal appetite, spontaneous sweating, or night sweats. Also used as a simple tonic decoction during recovery from illness.

E Jiao
E Jiao Xian He Cao 15–30g : E Jiao 10g (melted into decoction)

Xian He Cao astringes to stop active bleeding, while E Jiao (donkey-hide gelatin) nourishes Blood and Yin and also has hemostatic properties as a 'flesh and blood' substance. The combination both stops the bleeding and replenishes what has been lost, preventing the weakness that follows blood loss.

When to use: Chronic or heavy uterine bleeding (崩漏), coughing blood from lung conditions, or any bleeding accompanied by signs of Blood deficiency such as pallor, dizziness, and dry skin.

Bai Mao Gen
Bai Mao Gen 1:1, typically Xian He Cao 15–30g : Bai Mao Gen 15–30g

Bai Mao Gen (Imperata rhizome) is sweet and cold, cooling blood and promoting urination. Paired with Xian He Cao's astringent hemostatic action, the combination clears Heat from the blood while simultaneously stopping the bleeding. The cooling nature of Bai Mao Gen compensates for Xian He Cao's neutrality when Heat is the primary driver of bleeding.

When to use: Blood in the urine (hematuria), nosebleeds due to Heat, or intestinal bleeding with signs of Heat such as bright red blood and a sensation of burning.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Bai Ji
Xian He Cao vs Bai Ji

Both Xian He Cao and Bai Ji (Bletilla rhizome) are hemostatic herbs, but they work through different mechanisms and excel in different locations. Bai Ji is bitter, sweet, astringent, and slightly cold. It is strongest for Lung bleeding (hemoptysis) and stomach bleeding because it physically binds wounds and promotes tissue healing. Xian He Cao has a broader range: it can be used for bleeding anywhere in the body, and its neutral temperature makes it more versatile across Hot and Cold patterns. Additionally, Xian He Cao has a tonifying action that Bai Ji lacks, making it better for patients who are also fatigued or depleted.

Di Yu
Xian He Cao vs Di Yu

Both herbs stop bleeding in the lower body, particularly intestinal and uterine bleeding. Di Yu (Sanguisorba root) is bitter, sour, and slightly cold, giving it stronger Heat-clearing and cooling Blood capacity, making it the preferred choice for acute bloody dysentery with Heat signs. Xian He Cao, being neutral, is more suitable for chronic or deficiency-type lower bleeding and is better when fatigue accompanies the bleeding. Di Yu focuses almost exclusively on lower-body bleeding, while Xian He Cao treats bleeding at any location.

Ce Bai Ye
Xian He Cao vs Ce Bai Ye

Both are widely used hemostatic herbs, but Ce Bai Ye (Platycladus leaf) is bitter, astringent, and slightly cold, entering the Lung, Liver, and Large Intestine channels. It excels at cooling blood and stopping bleeding when Heat is the predominant cause. Xian He Cao is neutral and can be used regardless of whether the bleeding is from Heat or Cold, making it more universally applicable. Xian He Cao also has the unique advantage of tonifying deficiency, which Ce Bai Ye does not offer.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Xian He Cao

Xian He Cao (Agrimonia pilosa) may occasionally be confused with other Agrimonia species or with other herbs called "Long Ya Cao" in regional folk usage. The root bud portion (He Cao Ya, 鹤草芽) is a separate medicinal product used as an antiparasitic and should not be mixed with or substituted for the aerial parts (whole herb). The closely related European species Agrimonia eupatoria has similar but not identical phytochemistry and is sometimes encountered in international markets as a substitute. When purchasing, verify the reddish-brown lower stems, characteristic pinnate leaves with alternating large and small leaflets, and the hooked-spine calyx tubes typical of the authentic herb.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Xian He Cao

Non-toxic

Xian He Cao is generally considered non-toxic and is classified as safe by the Chinese Pharmacopoeia. However, clinical case reports have documented occasional adverse reactions, particularly at high doses, including visual disturbance (optic neuritis), respiratory difficulty, skin rashes, headache, facial flushing, nausea, vomiting, and profuse sweating. Very rare cases of anaphylactic shock have been reported. When used within standard dosage ranges (6-15g for routine use), the herb has an excellent safety record. The root bud (He Cao Ya, 鹤草芽), used as an antiparasitic, is a different medicinal part with different safety considerations and should not be confused with the aerial herb.

Contraindications

Situations where Xian He Cao should not be used or requires extra caution

Avoid

Known allergy or hypersensitivity to Xian He Cao (Agrimonia pilosa) or other Rosaceae family plants. Rare but serious adverse reactions including anaphylactic shock have been reported.

Caution

Use with caution in bleeding from unidentified causes. While Xian He Cao is a hemostatic herb, persistent or severe bleeding requires proper diagnosis before relying on any herbal treatment.

Caution

Use with caution in patients with Blood stasis patterns. As a strongly astringent herb, it may retain stasis and worsen conditions where Blood stasis is the primary pathology, potentially trapping the pathogen inside.

Caution

Caution advised when using very large doses (above 60g). Clinical reports have noted adverse reactions at high doses including visual disturbance, respiratory difficulty, skin rashes, nausea, vomiting, and profuse sweating.

Caution

Use with caution in patients taking anticoagulant or antiplatelet medications (warfarin, aspirin, etc.), as the herb's tannin content and hemostatic properties may interfere with these drugs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Caution advised during pregnancy. While Xian He Cao is not classically listed among strongly prohibited pregnancy herbs, its astringent and Blood-moving properties warrant careful consideration. Some compound formulations containing Xian He Cao carry explicit pregnancy contraindications. The herb's tannin content and its documented effects on platelet function and blood coagulation suggest it could theoretically influence uterine blood flow. Pregnant women should only use this herb under the direct guidance of a qualified practitioner.

Breastfeeding

No specific studies exist on the transfer of Xian He Cao constituents into breast milk. While the herb is generally considered mild and safe at standard doses, its high tannin content could theoretically affect nutrient absorption in the nursing infant if the mother consumes large doses. There is no classical prohibition against its use during breastfeeding, but as a precaution, nursing mothers should use it only at standard doses and under practitioner guidance.

Children

Xian He Cao can be used in children at reduced doses appropriate to the child's age and weight, typically one-third to one-half of the adult dose. It has traditionally been used for children's summer fatigue ("zhu xia") at around 15g with red dates. The herb's mild, neutral nature makes it relatively gentle for pediatric use. Children should always be given this herb under the supervision of a qualified practitioner, and parents should monitor for any digestive discomfort.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xian He Cao

Anticoagulant and antiplatelet drugs (warfarin, aspirin, clopidogrel): Xian He Cao contains tannins and has demonstrated both pro-coagulant and antiplatelet effects in laboratory studies. This dual action creates an unpredictable interaction potential with blood-thinning medications. Concurrent use may either enhance or counteract anticoagulant effects. Monitoring of INR/coagulation parameters is recommended if co-administration is unavoidable.

Iron supplements and tetracycline antibiotics: The high tannin content (up to 16.4% in the leaves) can chelate iron and bind to proteins, reducing the absorption of oral iron preparations and certain antibiotics such as tetracyclines. These medications should be taken at least 2 hours apart from Xian He Cao.

Antidiabetic medications: Preclinical research suggests Xian He Cao extract has blood glucose-lowering effects. Patients on insulin or oral hypoglycaemic agents should be aware of potential additive effects on blood sugar levels.

Dietary Advice

Foods and dietary considerations when taking Xian He Cao

Avoid spicy, hot, and stimulating foods (chilli, pepper, mustard, strong alcohol) while taking Xian He Cao, as these can aggravate bleeding conditions and counteract the herb's hemostatic effects. Raw garlic and radish (luobo) are traditionally advised against during use, as they may reduce the herb's efficacy. When using the herb for tonifying weakness, pairing it with nourishing foods such as red dates, lean meats, and warm congee can support the therapeutic effect.

Botanical Description

Physical characteristics and morphology of the Xian He Cao source plant

Agrimonia pilosa Ledeb. (Hairy Agrimony) is a perennial herbaceous plant in the Rosaceae (rose) family. It produces one or more erect, branched stems growing 50 to 120 cm tall from a short, often tuberous rootstock with many lateral roots. The entire plant is covered in soft white hairs.

The leaves are alternate and oddly pinnate (compound), with 3 to 9 elliptical leaflets that have sharply serrated margins and numerous yellow glandular dots on both surfaces. Notably, larger and smaller leaflets alternate along the leaf axis. Slender terminal and axillary racemes (flower spikes) bear small yellow five-petalled flowers from July to September. Each flower sits on a short stalk with two trident-shaped bracts at its base. The calyx tube is densely covered in hooked spines, which later enclose the achene (fruit) and aid in seed dispersal. Fruits ripen from September to October.

The plant grows along roadsides, on hillsides, in wastelands, and in grasslands. It thrives in a wide range of soils including sandy, loamy, and clay types, and prefers sunny to semi-shaded positions in temperate climates across East Asia, northern Asia, and parts of Eastern Europe.

Sourcing & Harvesting

Where Xian He Cao is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Summer to autumn, when the stems and leaves are lush but before or just as flowering begins.

Primary growing regions

Widely distributed throughout most of China. The primary producing regions recognized for quality are Zhejiang, Jiangsu, and Hubei provinces. Additional production comes from Anhui, Fujian, Guangdong, Hebei, Shandong, Hunan, and Yunnan. Unlike many herbs, Xian He Cao does not have a single strongly defined dao di (terroir) region, as it grows abundantly as a common wayside herb across China. Its broad geographic range from northern and eastern Europe through northern Asia to Japan and Indo-China also makes it available internationally.

Quality indicators

Good quality Xian He Cao should be young and tender with abundant leaves still attached. The stems should be reddish-brown in the lower portions and greenish-brown above, with visible longitudinal grooves and ridges, and a hollow cross-section. The leaves should be dark green (though they will be wrinkled and somewhat curled when dried). The herb should have a faint aroma and a slightly bitter taste. Avoid material that is mostly bare stems with few leaves, overly woody, or has turned dark brown or black. The presence of yellow flowers on the herb indicates it was harvested too late, past the ideal window.

Classical Texts

Key passages from the classical Chinese medical texts that describe Xian He Cao and its therapeutic uses

《履巉岩本草》 (Lǚ Chán Yán Běn Cǎo)

Original: 「味辛涩,温,无毒。」

Translation: "Acrid and astringent in taste, warm in nature, non-toxic."

This is one of the earliest recorded descriptions of the herb's properties.

《滇南本草》 (Diān Nán Běn Cǎo) by Lan Mao, Ming Dynasty

Original: 「治妇人月经或前或后,赤白带下,面寒腹痛,日久赤白血痢。」

Translation: "Treats women's irregular menstruation (early or late), red and white vaginal discharge, facial pallor with abdominal pain, and long-standing bloody or mucoid dysentery."

《百草镜》 (Bǎi Cǎo Jìng)

Original: 「下气活血,理百病,散痞满;跌扑吐血,血崩,痢,肠风下血。」

Translation: "Descends Qi and invigorates Blood, manages a hundred diseases, disperses distension and fullness; [treats] traumatic blood-spitting, uterine hemorrhage, dysentery, and intestinal wind with bloody stool."

《现代实用中药》 (Xiàn Dài Shí Yòng Zhōng Yào, Modern Practical Chinese Medicine)

Original: 「为强壮性收敛止血剂,兼有强心作用。适用于肺病咯血,肠出血,胃溃疡出血,子宫出血,齿科出血,痔血,肝脓疡等症。」

Translation: "A strengthening, astringent hemostatic agent with additional cardiotonic action. Suitable for pulmonary hemoptysis, intestinal bleeding, gastric ulcer bleeding, uterine bleeding, dental bleeding, hemorrhoidal bleeding, liver abscess, and similar conditions."

Historical Context

The history and evolution of Xian He Cao's use in Chinese medicine over the centuries

Xian He Cao entered the formal herbal literature relatively late. Its earliest appearance in classical materia medica was in the Song Dynasty's Ben Cao Tu Jing (本草图经, Illustrated Classic of Materia Medica), where it was recorded under the name Long Ya Cao (龙牙草, "Dragon's Tooth Herb") due to the pointed, tooth-like shape of its flower buds. Its more common name Xian He Cao (仙鹤草, "Immortal Crane Herb") derives from a folk legend: two scholars traveling to the capital examinations encountered a crane carrying a sprig of the herb in its beak. When the crane dropped it, the scholar suffering from a nosebleed chewed the herb and was cured. They later named it in honour of the crane that delivered the remedy.

Despite its late entry into the formal texts, the herb was widely used in folk medicine long before, earning the folk name Tuo Li Cao (脱力草, "Fatigue-Relieving Herb") for its remarkable ability to restore strength in exhausted labourers. The Ming Dynasty text Dian Nan Ben Cao (滇南本草) by Lan Mao was among the first to formally record its uses. Later, Ben Cao Gang Mu Shi Yi (本草纲目拾遗) and Bai Cao Jing (百草镜) both expanded the documentation of its clinical effects. The Ming physician Jiang Yi notably used Xian He Cao for esophageal and stomach cancers, writing that for conditions others considered untreatable, this herb was effective in nine out of ten cases. In modern times, National Master of Chinese Medicine Gan Zuwang created the famous "Three Immortals Decoction" (San Xian Tang), combining Xian He Cao with Xian Ling Pi and Xian Mao to treat chronic fatigue syndromes.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Xian He Cao

1

Phytochemical and Pharmacological Review of Agrimonia pilosa (Review, 2022)

Jin T, Chi L, Ma C. Evidence-Based Complementary and Alternative Medicine, 2022, 2022:3742208.

A comprehensive review of the phytochemistry and pharmacology of A. pilosa. Identified over 100 secondary metabolites across six classes (flavonoids, isocoumarins, triterpenes, phloroglucinol derivatives, tannins, and organic acids) and documented antitumor, anti-inflammatory, antioxidant, antibacterial, and antidiabetic activities in preclinical studies.

PubMed
2

Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology of A. pilosa (Review, 2022)

Wen S, Zhang X, Wu Y, Yu S, Zhang W, Liu D, Yang K, Sun J. Heliyon, 2022, 8(8):e09972.

A thorough review identifying over 252 chemical compounds from A. pilosa. Documented anti-inflammatory, anticancer, antioxidant, and analgesic effects. Noted the herb's effectiveness in treating enteritis, gastric ulcers, and gastrointestinal bleeding and reviewed available toxicology data.

PubMed
3

Current Progress and Outlook for Agrimonolide from Agrimonia pilosa (Review, 2023)

Huang T, Zhao CC, Xue M, Cao YF, Chen LK, Chen JX, Sun YJ, Zeng J. Pharmaceuticals (Basel), 2023, 16(2):150.

Review of agrimonolide, a key isocoumarin from A. pilosa. Agrimonolide crosses the blood-brain barrier and shows multitarget activity against cancer, inflammation, liver injury, myocardial damage, and diabetes in cell-based studies. Showed no cytotoxicity across a range of concentrations, but most evidence comes from in vitro studies and substantial human data is still lacking.

4

Antiplatelet Effect of Agrimonia pilosa (In vitro study, 1985)

Published in a pharmacology journal, 1985.

An early pharmacological study showing that the water extract of A. pilosa produced dose-dependent inhibition of collagen-induced platelet aggregation in platelet-rich plasma, with an IC50 of about 3.5 mg/ml. It also inhibited aggregation induced by ADP and calcium ionophore A23187. This is relevant to understanding the herb's dual role in both hemostasis and blood-invigorating effects.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.