Herb Whole plant / Aerial parts (全草 quán cǎo)

Pei Lan

Eupatorium Herb · 佩兰

Eupatorium fortunei Turcz. · Herba Eupatorii

Also known as: Fortune's Eupatorium Herb

Images shown are for educational purposes only

Pei Lan is a fragrant herb that specialises in resolving digestive problems caused by excess moisture and humidity in the body. It is best known for treating bloating, nausea, loss of appetite, bad breath, and a sweet sticky taste in the mouth. It is also a go-to herb for summer ailments caused by heat and humidity, such as feeling heavy-headed, feverish, and sluggish.

TCM Properties

Temperature

Neutral

Taste

Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)

Channels entered

Spleen, Stomach, Lungs

Parts used

Whole plant / Aerial parts (全草 quán cǎo)

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What This Herb Does

Every herb has a specific set of actions — here's what Pei Lan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Pei Lan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Pei Lan performs to restore balance in the body:

How these actions work

'Transforms dampness aromatically' means Pèi Lán uses its fragrant nature to cut through Dampness that has accumulated in the middle burner (the digestive system). When Dampness clogs the Spleen and Stomach, digestion stalls and the person feels bloated, nauseous, and heavy. Pèi Lán's aromatic quality penetrates and disperses this Dampness, restoring normal digestive movement. It is especially valued for treating a condition called pí dàn (脾瘅, 'Spleen Dampness-Heat'), where Dampness and Heat accumulate in the Spleen channel and produce a characteristic sweet, greasy taste in the mouth, excessive saliva, and bad breath.

'Awakens the Spleen and opens the appetite' describes how the herb revives sluggish digestive function. When Dampness weighs down the Spleen, appetite disappears and food feels unappetising. Pèi Lán's fragrant, pungent quality 'wakes up' the Spleen, helping it resume its job of transforming food and fluids. This is why it is commonly used for people who feel full and bloated with no desire to eat, or who have a thick, greasy tongue coating.

'Releases the exterior and resolves summerheat' means Pèi Lán can address the early stages of illness caused by summerheat and Dampness, such as feeling feverish, heavy-headed, and chest-congested during hot, humid weather. Its neutral temperature (unlike Huò Xiāng, which is slightly warm) makes it particularly suitable when there is a Damp-Heat component, as it resolves Dampness without adding extra warmth.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Pei Lan is used to help correct these specific patterns.

Why Pei Lan addresses this pattern

Pèi Lán directly targets the pathomechanism of this pattern: Dampness congesting the Spleen and Stomach, impairing their transport and transformation functions. Its acrid taste disperses and moves stagnation, while its aromatic nature penetrates turbid Dampness that ordinary drying herbs cannot reach. Because it enters both the Spleen and Stomach channels and has a neutral temperature, it resolves Dampness without generating unwanted Heat or further injuring fluids. It is the classical herb of choice for pí dàn (Spleen Dampness), as referenced in the Sù Wèn's discussion of treating a sweet taste in the mouth with 'lán' (orchid/eupatorium) to 'remove stale Qi.'

A practitioner would look for one or more of these signs

Post-Surgical Constipation And Bloating

Epigastric and abdominal distension and fullness

Nausea

Nausea and vomiting

Loss Of Appetite

Poor appetite, no desire to eat

Bad Breath

Sweet, greasy taste in the mouth with bad breath

Excessive Salivation

Excessive sticky saliva

Commonly Used For

These are conditions where Pei Lan is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

TCM Interpretation

In TCM, chronic bad breath is rarely viewed as a simple oral hygiene problem. It most often reflects internal Dampness or Damp-Heat accumulating in the Spleen and Stomach. When the Spleen fails to properly transform food and fluids, a turbid, stale residue (called 'chén qì' or stale Qi) builds up. This turbid Qi rises upward to the mouth, producing foul breath along with a characteristic sweet, greasy taste and excessive sticky saliva. The Sù Wèn describes this condition as 'pí dàn' (脾瘅), linking it to overconsumption of rich, sweet, and fatty foods that overwhelm the Spleen's capacity.

Why Pei Lan Helps

Pèi Lán is regarded as the principal herb for this presentation since classical times. Its aromatic nature specifically targets the stale, turbid Qi that produces the foul odour, acting to 'remove stale Qi' (除陈气) as described in the Sù Wèn. Its acrid taste disperses the congested Dampness in the Spleen and Stomach, while its channel affinity for both organs ensures the herb reaches the root of the problem. Because it is neutral in temperature, it can address both cold-Dampness and Damp-Heat presentations without aggravating either. In clinical practice, Pèi Lán is often combined with Huò Xiāng and Huáng Lián to address bad breath from Spleen Damp-Heat.

Also commonly used for

Nausea

Nausea and vomiting due to Dampness in the Stomach

Loss Of Appetite

Reduced appetite with heavy, greasy tongue coating

Gastritis

Acute gastritis, particularly in summer with Dampness involvement

Indigestion

Functional dyspepsia with Dampness signs

Influenza

Summer flu with combined heat and humidity symptoms

Excessive Salivation

Excessive thick, sticky saliva

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Neutral

Taste

Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)

Channels Entered

Spleen Stomach Lungs

Parts Used

Whole plant / Aerial parts (全草 quán cǎo)

Dosage & Preparation

These are general dosage guidelines for Pei Lan — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

5-10g

Maximum dosage

Up to 15g of dried herb in acute Dampness or summer-Heat conditions. Fresh herb can be used at double the dried dose (up to 20-30g). Do not exceed these doses or use long-term.

Dosage notes

For standard Dampness obstruction of the middle burner, use 5-10g of the dried herb in decoction. Fresh Pei Lan (鲜佩兰) is preferred for summer-Heat conditions and can be used at roughly double the dried dose (10-20g), as its aromatic volatile oils are better preserved. When treating Spleen Dampness with a sweet, greasy mouth taste or bad breath (the classical pi dan pattern), moderate doses of 6-10g are typical, often paired with Huo Xiang. The dried form retains therapeutic value but loses some aromatic potency compared to fresh.

Preparation

Add Pei Lan near the end of decoction (后下, hou xia), typically in the last 5-10 minutes. Its therapeutic value depends heavily on its aromatic volatile oils, which are quickly lost with prolonged boiling. This is especially important for the dried form. Fresh Pei Lan (鲜佩兰) should also be added late in the decoction process.

Common Herb Pairs

These ingredients are traditionally combined with Pei Lan for enhanced therapeutic effect

Huo Xiang
Huo Xiang 1:1 (typically 10g each)

This is the most classic and widely used pair for Pèi Lán. Both herbs aromatically transform Dampness and resolve Summerheat, but they complement each other: Huò Xiāng (slightly warm) is stronger at dispersing exterior pathogenic factors and stopping vomiting, while Pèi Lán (neutral) excels at awakening the Spleen and clearing internal turbid Dampness, especially Damp-Heat. Together they provide comprehensive aromatic Dampness resolution from the exterior to the interior without being overly warming.

When to use: Whenever Dampness obstructs the middle burner with symptoms like nausea, bloating, greasy tongue coating, poor appetite, or during summer illness with combined heat and humidity. Also for bad breath and sweet, sticky mouth taste.

Huang Lian
Huang Lian Pèi Lán 10g : Huáng Lián 3–6g

Pèi Lán aromatically transforms Dampness from the Spleen while Huáng Lián's bitter cold nature clears Heat and dries Dampness from the Stomach. Together they address Damp-Heat in the middle burner from two angles: Pèi Lán works through fragrant dispersal and Huáng Lián through bitter draining. This combination is particularly effective for the 'pí dàn' presentation with bad breath, sweet greasy mouth taste, and thick yellow tongue coating.

When to use: Damp-Heat accumulation in the Spleen and Stomach causing bad breath, foul mouth taste, nausea, or epigastric discomfort with a yellow, greasy tongue coating.

Cang Zhu
Cang Zhu 1:1 (typically 10g each)

Pèi Lán aromatically transforms Dampness with a gentle, neutral approach, while Cāng Zhú vigorously dries Dampness with its warm, bitter, and pungent nature. The combination provides both gentle aromatic penetration and forceful drying action, making it more effective against stubborn Dampness than either herb alone. Cāng Zhú also strengthens the Spleen to prevent Dampness from reforming.

When to use: Severe Dampness obstructing the middle burner with pronounced bloating, heavy limbs, loose stools, and thick greasy tongue coating, particularly when Dampness is cold in nature.

He Ye
He Ye Pèi Lán 10g : Hé Yè 10g (or one fresh lotus leaf)

Both herbs resolve Summerheat, but through different mechanisms: Pèi Lán aromatically transforms Dampness in the middle burner, while Hé Yè (lotus leaf) clears Summerheat, raises clear Yáng, and dispels turbidity. Together they address summer illness from both the Dampness and Heat angles, with Hé Yè lifting the clear Qi upward while Pèi Lán clears the turbid Dampness below.

When to use: Summer heat illness with combined Dampness: headache, dizziness, chest oppression, nausea, low fever, and fatigue during hot, humid weather.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Huo Xiang
Pei Lan vs Huo Xiang

Both aromatically transform Dampness and resolve Summerheat, and they are often used together. The key difference: Huò Xiāng is slightly warm and has a stronger ability to release the exterior (dispel Wind-Cold) and stop vomiting, making it better for acute nausea/vomiting and exterior patterns. Pèi Lán is neutral in temperature, making it more suitable when there is a Damp-Heat component, and it is specifically superior for the 'pí dàn' (Spleen Dampness-Heat) presentation with sweet, greasy mouth taste and bad breath. When the condition leans warm, choose Pèi Lán; when it leans cold with prominent vomiting, choose Huò Xiāng.

Cang Zhu
Pei Lan vs Cang Zhu

Both resolve Dampness in the middle burner, but through different mechanisms. Cāng Zhú is warm, bitter, and pungent, working by vigorously drying and burning off Dampness, which also makes it suitable for Wind-Damp painful obstruction and exterior patterns. Pèi Lán works aromatically rather than by drying, making it gentler and better tolerated when fluids are already somewhat depleted or when Damp-Heat is present. Cāng Zhú is the stronger choice for cold-Dampness; Pèi Lán is preferred for Damp-Heat or when a milder approach is needed.

Sha Ren
Pei Lan vs Sha Ren

Both awaken the Spleen and address Dampness-related digestive problems. Shā Rén is warm and enters the Kidney channel as well, giving it additional abilities to warm the middle, stop diarrhoea, and calm the foetus. Pèi Lán is neutral, focused purely on aromatic Dampness transformation and Summerheat resolution, and is better for Damp-Heat presentations. Choose Shā Rén when the pattern includes cold in the middle burner, diarrhoea, or pregnancy-related nausea; choose Pèi Lán when the mouth is sweet and greasy with bad breath or when Summer-Heat is involved.

Therapeutic Substitutes

Legitimate clinical replacements when Pei Lan is unavailable, restricted, or contraindicated

Huo Xiang

Huo Xiang
Huo Xiang 藿香
Patchouli herb

Covers: Covers Pèi Lán's core actions of resolving dampness in the middle jiao (Spleen and Stomach), clearing turbid dampness, relieving nausea, poor appetite, and stifling chest sensation. Also addresses summer-heat dampness patterns. Multiple Chinese clinical sources document these two herbs as mutually interchangeable ('二药可以互代') for aromatic dampness-resolving purposes.

Does not cover: Huò Xiāng is slightly warm in thermal nature, whereas Pèi Lán is neutral. This makes Huò Xiāng less suitable when dampness is accompanied by heat signs, or in patients with a warm/heat constitution. Pèi Lán has a stronger reputation for clearing the distinctive 'sickly sweet' mouth taste (脾瘅) associated with Spleen dampness — Huò Xiāng's strength lies more in harmonising the Stomach and stopping nausea and vomiting.

Use when: When Pèi Lán is unavailable or difficult to source. Best suited to cold-damp or neutral-damp patterns in the middle jiao where the slight warmth of Huò Xiāng is not a concern. Avoid direct substitution in damp-heat patterns where the added warmth could aggravate heat.

Identity & Adulterants

Related species and common adulterations to be aware of when sourcing Pei Lan

The most important confusion historically is between Pei Lan (佩兰, Eupatorium fortunei, Asteraceae/daisy family) and Ze Lan (泽兰, Lycopus lucidus var. hirtus, Lamiaceae/mint family). These two herbs were conflated under the single name "Lan Cao" for centuries. They have completely different therapeutic actions: Pei Lan resolves Dampness and awakens the Spleen, while Ze Lan invigorates Blood and reduces swelling. To distinguish them: Pei Lan has round stems with long internodes and smooth, glossy leaves that may be three-lobed; Ze Lan has slightly square stems with shorter internodes and hairy leaves. Shan Pei Lan (山佩兰, Eupatorium japonicum), a related species, is sometimes used as a local substitute. It has similar appearance but is a distinct species with somewhat different chemical composition.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Pei Lan

Non-toxic

Classified as non-toxic in the Chinese Pharmacopoeia and considered safe at standard doses for short-term use. However, modern phytochemical research has identified that Eupatorium fortunei contains low levels of pyrrolizidine alkaloids (PAs), including intermedine, lycopsamine, and their N-oxides. PAs are a class of naturally occurring compounds found across the Eupatorium genus that can be hepatotoxic (liver-damaging) with prolonged exposure. Risk assessments suggest that short-term intake at standard doses is unlikely to cause acute toxicity, but chronic or high-dose use warrants caution. The herb should be used for appropriate indications and not taken continuously over extended periods without clinical supervision.

Contraindications

Situations where Pei Lan should not be used or requires extra caution

Caution

Yin deficiency with internal Heat. Pei Lan is aromatic and drying in nature. In people with depleted Yin fluids and internal Heat, it may further damage Yin and worsen dryness symptoms such as dry mouth, thirst, and night sweats.

Caution

Qi deficiency. Classical sources including De Pei Ben Cao (得配本草) state that Pei Lan is contraindicated when Stomach Qi is deficient (胃气虚者禁用). Aromatic, dispersing herbs can further weaken already depleted Qi.

Caution

Blood deficiency or Blood dryness. The herb's aromatic, dispersing properties may further consume already depleted Blood and fluids.

Caution

Prolonged or high-dose use without Dampness. Modern research has identified pyrrolizidine alkaloids (PAs) in Eupatorium fortunei that may pose hepatotoxic risk with chronic use. The herb should only be used when a Dampness pattern is present, and long-term continuous use should be avoided.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

No specific pregnancy contraindication is traditionally recorded for Pei Lan, and it is not classified among the classical herbs prohibited during pregnancy. However, given the presence of pyrrolizidine alkaloids (PAs) identified in modern research, which have genotoxic potential, caution is advisable. Pregnant women should avoid prolonged use and only take it under professional guidance when clearly indicated (such as acute summer-Dampness illness). Fresh Pei Lan used briefly and at standard doses for specific conditions is generally considered acceptable by experienced practitioners.

Breastfeeding

No specific classical contraindication exists for breastfeeding. However, the pyrrolizidine alkaloids present in the herb could theoretically transfer through breast milk. As a precaution, breastfeeding mothers should use Pei Lan only when clearly needed for an acute condition, at standard doses, and for the shortest duration possible. Extended or high-dose use is not recommended during breastfeeding.

Children

Pei Lan can be used in children for summer-Dampness conditions, but at reduced doses proportional to age and body weight (typically one-third to one-half of the adult dose for older children). Fresh Pei Lan is often preferred for paediatric summer complaints due to its milder, lighter action. Given the pyrrolizidine alkaloid content, avoid prolonged use in children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Pei Lan

No well-documented pharmaceutical drug interactions have been established for Pei Lan in clinical literature. However, given that modern research has identified pyrrolizidine alkaloids (PAs) in this herb, theoretical caution is warranted with:

  • Hepatotoxic medications: Concurrent use with drugs that stress the liver (e.g. acetaminophen/paracetamol, certain statins, methotrexate) could theoretically compound hepatic burden.
  • CYP450-metabolised drugs: Some Eupatorium species' volatile oils may affect hepatic enzyme activity, though this has not been specifically confirmed for E. fortunei at clinical doses.

These are theoretical considerations based on the herb's chemical constituents, not documented clinical interactions. Nevertheless, patients on long-term hepatotoxic medications should inform their practitioner before using Pei Lan.

Dietary Advice

Foods and dietary considerations when taking Pei Lan

While taking Pei Lan for Dampness conditions, avoid greasy, oily, and rich foods that generate further Dampness. Cold and raw foods (salads, iced drinks, raw fruits in excess) should also be limited, as they impair Spleen function and counteract the herb's Dampness-transforming action. Light, easily digestible, warm-cooked foods are ideal. Avoid excessive sweet foods, as the herb is specifically used to address conditions caused by sweet, greasy dietary overindulgence.

Botanical Description

Physical characteristics and morphology of the Pei Lan source plant

Eupatorium fortunei Turcz. is a perennial herbaceous plant in the Asteraceae (daisy) family, growing 40 to 100 cm tall from creeping, reddish-brown rhizomes. The stems are erect, green or reddish-purple, with few branches and sparse fine hairs. The mid-stem leaves are the largest, typically divided into three segments (3-sect or 3-partite), with short petioles. The terminal leaf lobe is narrowly elliptic to lance-shaped, 5 to 10 cm long and 1.5 to 2.5 cm wide, with toothed margins. Lower leaves are smaller and wither by flowering time.

Numerous small flower heads form dense, flat-topped clusters (compound corymbs) at the stem tips. Each head contains 4 to 6 small tubular florets that are white to slightly pinkish-red, with purplish-red bracts. The fruits are small, cylindrical achenes that turn blackish-brown when ripe, topped with white pappus hairs. The entire plant is strongly aromatic, with a scent likened to lavender when crushed. It flowers and fruits from July through November.

The plant grows naturally along roadsides, in thickets, and beside streams at elevations of 450 to 2,000 metres, preferring warm, humid conditions with well-drained, fertile soil. It is native to East Asia, found across much of China as well as Japan, Korea, and Thailand. Though somewhat rare in the wild, it is widely cultivated.

Sourcing & Harvesting

Where Pei Lan is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Summer and autumn, harvested in two cuttings (typically July and September). Best harvested at midday on a sunny day, when volatile oil content is highest.

Primary growing regions

Widely distributed across China, including Jiangsu, Zhejiang, Hebei, Shandong, Anhui, Guangdong, Guangxi, Hubei, Hunan, Sichuan, Guizhou, Yunnan, and Shaanxi provinces. Jiangsu has the largest production volume and is considered a primary commercial source. Fujian province (especially eastern and southern Fujian) has favourable climate and soil conditions, with large areas of both wild and cultivated Pei Lan. The herb is also found in Japan, Korea, and Thailand.

Quality indicators

Good quality Pei Lan consists of cut stem-and-leaf segments. The stems should be cylindrical, yellowish-brown or yellowish-green in colour, sometimes with a purple tinge, with clearly visible nodes and vertical ridges. The cross-section shows a white pith centre or may be hollow. The leaves should be green-brown, opposite on the stem, and though often crinkled and somewhat broken, should retain their colour. The most important quality indicator is aroma: high-quality Pei Lan has a strong, pleasant, characteristic fragrance. The taste should be slightly bitter. Avoid material that has lost its fragrance, is heavily blackened or mouldy, or has been over-dried to the point of crumbling to dust. Fresh Pei Lan (鲜佩兰) should have vibrant green leaves and an intense aromatic scent.

Classical Texts

Key passages from the classical Chinese medical texts that describe Pei Lan and its therapeutic uses

Huang Di Nei Jing, Su Wen (黄帝内经·素问), Qi Bing Lun (奇病论)

Chinese: 「津液在脾,故令人口甘也,此肥美之所发也……其气上溢,转为消渴,治之以兰,除陈气也。」

English: "When fluids accumulate in the Spleen, it causes a sweet taste in the mouth; this arises from overindulgence in rich foods… the Qi rises and overflows, transforming into wasting-thirst. Treat it with Lan [Pei Lan], to dispel stale Qi."

This is perhaps the most famous classical reference to Pei Lan, establishing its role in treating Spleen Dampness with a sweet, greasy taste in the mouth, a condition known as pi dan (脾瘅).


Shen Nong Ben Cao Jing (神农本草经)

Chinese: 「兰草,味辛,平。主利水道,杀蛊毒。」

English: "Lan Cao [Pei Lan]: acrid flavour, neutral nature. It mainly promotes the water passages and kills parasitic toxins."


Ben Cao Gang Mu (本草纲目), Li Shizhen

Chinese: 「兰草走气道,故能利水道,除痰癖,杀蛊辟恶,而为消渴良药。」

English: "Lan Cao moves through the Qi pathways, and therefore can promote the water passages, dispel phlegm accumulation, kill parasites and ward off foulness, making it an excellent medicine for wasting-thirst."


Ben Cao Jing Shu (本草经疏)

Chinese: 「兰草辛平能散结滞,芬芳能除秽恶,则上来诸证自瘳,大都开胃除恶,清肺消痰,散郁结之圣药也。」

English: "Lan Cao, acrid and neutral, can disperse stagnation and binding; its fragrance can eliminate foulness and filth. Thus the aforementioned conditions resolve naturally. In general, it is a supreme medicine for opening the Stomach, dispelling foulness, clearing the Lungs, dissolving phlegm, and dispersing constrained stagnation."

Historical Context

The history and evolution of Pei Lan's use in Chinese medicine over the centuries

Pei Lan has one of the longest documented histories of any Chinese herb, reaching back to the earliest strata of Chinese civilization. It first appeared in the Shen Nong Ben Cao Jing under the name Lan Cao (兰草), classified as an upper-grade herb. Remarkably, preserved achenes (fruits) and leaf fragments of this plant were discovered in the Mawangdui tomb near Changsha, Hunan, dating to the early Western Han dynasty (around 168 BCE), placed inside a sachet, confirming its ancient use as an aromatic for warding off disease and impurity.

The herb holds deep cultural significance in Chinese literature. The great poet Qu Yuan (屈原, c. 340–278 BCE) famously wrote in the Li Sao (离骚): "I strung autumn orchids to wear as my girdle" (纫秋兰以为佩). The "lan" of ancient poetry refers to this fragrant herb, not the modern orchid (which is a different plant family). Ancient people wore Pei Lan on their bodies or placed it among clothing to repel insects, freshen the air, and symbolise moral purity. Its very name, Pei Lan (佩兰, "orchid to be worn"), derives from this custom. The classical bathing ritual known as "yu lan tang" (浴兰汤, "orchid-water bath"), referenced in Qu Yuan's Jiu Ge (九歌), used Pei Lan-infused water for purification.

An important historical challenge has been the persistent confusion between Pei Lan (佩兰, Eupatorium fortunei, Asteraceae family) and Ze Lan (泽兰, Lycopus lucidus, Lamiaceae family). Li Shizhen in the Ben Cao Gang Mu clarified that these are "one type, two kinds" (一类二种) with distinct therapeutic actions: Pei Lan works through the Qi aspect and excels at resolving Dampness, while Ze Lan works through the Blood aspect and excels at invigorating Blood. This distinction remains clinically important today.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Pei Lan

1

Pyrrolizidine Alkaloid Analysis and In Vitro Neurotoxicity Assessment (Laboratory study, 2021)

Zhang Y, Yang FF, Chen H, Qi YD, Si JY, Wu Q, Liao YH. Food and Chemical Toxicology, 2021, 151:112151.

Researchers analysed 30 batches of Pei Lan herb and 4 commercial products for pyrrolizidine alkaloid (PA) content. They identified 8 PAs, with intermedine N-oxide and lycopsamine N-oxide being most abundant. Total PA levels varied widely (0.18 to 61.81 micrograms per gram in raw herb). Risk assessment suggested short-term intake was unlikely to cause acute toxic effects, but chronic use warranted caution. In laboratory cell models, some of these alkaloids showed the ability to inhibit neural progenitor cell growth.

2

Hepatotoxicity of Alkaloids from Eupatorium fortunei: Metabolomics and Proteomics Study (Preclinical, 2022)

Published in Toxins (MDPI), 2022, 14(11):765.

This mouse study investigated the liver toxicity of total alkaloids extracted from Pei Lan. When given concentrated alkaloid extracts, mice showed decreased body and liver weights, elevated liver enzymes (AST and ALT), and liver cell damage including fibrosis. The study found that the alkaloids disrupted glycerophospholipid metabolism in liver cells, leading to inflammation and cell death. Note: this used concentrated alkaloid extracts at high doses, not the whole herb at standard clinical doses.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.