Shi Gao Tang

Gypsum Decoction · 石膏湯

Also known as: San Huang Shi Gao Tang (三黄石膏汤) — the version with added Sheng Jiang, Da Zao, and Xi Cha from Tao Hua's Shang Han Liu Shu

A classical formula for severe febrile illness where the body has both an unresolved surface-level infection and intense internal Heat. It combines strong heat-clearing herbs with mild sweat-inducing herbs to address both the exterior symptoms (fever without sweating, body heaviness) and deep interior Heat (restlessness, delirium, dry mouth) at the same time.

Origin Wài Tái Bì Yào (外台秘要), citing Shēn Shī Fāng (深师方) — Táng dynasty, 752 CE
Composition 7 herbs
Shi Gao
King
Shi Gao
Ma Huang
Deputy
Ma Huang
Dan Dou Chi
Deputy
Dan Dou Chi
Huang Qin
Assistant
Huang Qin
Huang Lian
Assistant
Huang Lian
Huang Qi
Assistant
Huang Qi
Zhi Zi
Assistant
Zhi Zi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Gao Tang is designed to correct these specific patterns.

Why Shi Gao Tang addresses this pattern

This is the primary pattern Shi Gao Tang addresses. In this scenario, an external pathogen (often Wind-Cold) has invaded the body's surface but has not been properly expelled. Meanwhile, the pathogen has also begun to transform into Heat internally, creating blazing Fire in all three Burners. The patient presents with a trapped exterior (no sweating, body heaviness, muscular stiffness) alongside severe interior Heat signs (high fever, restlessness, delirium, dry nose and mouth).

The formula resolves both aspects simultaneously: Shi Gao, Ma Huang, and Dan Dou Chi release the exterior obstruction to restore sweating, while the combination of Huang Qin, Huang Lian, Huang Bai, and Zhi Zi purges the interior Fire-toxin from all three Burners. This dual approach ensures that clearing the interior does not lock the exterior pathogen in, and releasing the exterior does not worsen the internal Heat.

A practitioner would look for one or more of these signs

High Fever

Intense, unremitting fever (壮热) that does not break

Lack Of Sweating

No sweating despite high fever

Back Heaviness

Body feels heavy, muscles stiff and tight (拘挛)

Dry Nose

Nasal dryness

Thirst

Intense thirst with desire to drink

Insomnia

Restlessness and inability to sleep

Delirium

Mental confusion, incoherent speech, or delirium

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Gao Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Exterior Cold with Interior Heat Heat Toxin in all Three Burners

TCM Interpretation

In TCM, prolonged high fever that fails to respond to initial treatment often indicates a complex situation where the pathogen is stuck between the exterior and interior. The original external invasion (often Wind-Cold) has not been fully expelled, but the pathogen has already begun transforming into intense Heat inside the body. The Lungs lose their ability to regulate the skin and pores (hence no sweating), while the Stomach and other internal organs become overheated (hence the thirst, restlessness, and potential delirium). The key organs involved are the Lungs (which govern the exterior), the Stomach (the main site of Yangming Heat), and the Heart (whose spirit is disturbed by Fire). When all three Burners are affected, the Heat becomes systemic and difficult to resolve with any single-target approach.

Why Shi Gao Tang Helps

Shi Gao Tang is specifically designed for this dual-layered fever pattern. Shi Gao directly targets Yangming Stomach Heat, which is often the engine driving persistent high fever. Ma Huang and Dan Dou Chi open the exterior to restore sweating, which is one of the body's primary mechanisms for releasing Heat. Meanwhile, the combination of Huang Qin, Huang Lian, Huang Bai, and Zhi Zi ensures that toxic Heat is drained from every level of the body. This comprehensive approach breaks the cycle where the trapped exterior prevents Heat from escaping while the interior Fire prevents the exterior from resolving naturally.

Also commonly used for

Tonsillitis

With severe Heat and toxicity

Measles

When exterior symptoms persist alongside interior Heat

Pneumonia

With signs of both exterior constraint and interior Heat

Encephalitis

When presenting with delirium and high fever

Skin Rashes

Heat-toxin eruptions with concurrent exterior symptoms

Whooping Cough

With signs of intense Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Gao Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Gao Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Gao Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Gao Tang works at the root level.

This formula addresses a dangerous clinical scenario in febrile disease: the illness has been present for 8 to 9 days, and the pathogenic Heat has penetrated deeply into the Interior and is blazing through all Three Burners (upper, middle, and lower), yet the Exterior remains unresolved. The patient is caught in a double bind — intense Interior Heat produces high fever, mental confusion, delirium, restlessness, dry nose, thirst, and possible skin eruptions, while the lingering Exterior constraint causes absence of sweating, body heaviness, and muscular stiffness or cramping.

The core dilemma, as described in classical commentary, is that treating the Interior alone (with cold, bitter, toxin-clearing herbs) would leave the Exterior pathogen trapped and the cramping unresolved, while releasing the Exterior alone (with warm, dispersing herbs) would intensify the Interior toxin-Heat. The disease mechanism is one of concurrent Exterior constraint and Interior toxic Heat, with the Fire spreading across all three levels of the body's vertical axis. The Interior Heat may be so severe that it disturbs the Heart spirit (causing delirium or mania), forces Blood recklessly (causing nosebleeds), and steams the skin (causing a yellowish complexion).

The treatment principle therefore demands simultaneous action: releasing the Exterior and clearing Interior Heat at the same time. This is the strategy known as "resolving both Exterior and Interior" (表里双解, biǎo lǐ shuāng jiě), a critical approach when the two layers of disease cannot be addressed in sequence without worsening the other.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and acrid — bitter to drain Fire and dry Dampness across all Three Burners, acrid to release the Exterior and vent trapped Heat outward.

Channels Entered

Ingredients

7 herbs

The herbs that make up Shi Gao Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shi Gao

Shi Gao

Gypsum

Dosage 30g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Preparation Crush before decocting; decoct first for 20-30 minutes (先煎)

Role in Shi Gao Tang

The chief heat-clearing herb. Its sweet, acrid, and very cold nature powerfully drains Fire from the Yangming (Stomach) channel, clears interior Heat, and relieves restlessness and thirst. It also has a mild ability to release the muscle layer, bridging the exterior and interior treatment.
Deputies — Assists and enhances the King
Ma Huang

Ma Huang

Ephedra

Dosage 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Urinary Bladder
Preparation Remove nodes (去节)

Role in Shi Gao Tang

Opens the surface and induces sweating to release the exterior pathogen that remains trapped. Its warm, acrid nature disperses Wind-Cold from the muscle layer, helping resolve the absence of sweating, body heaviness, and muscular stiffness. Its warmth is counterbalanced by the large dose of cold Shi Gao.
Dan Dou Chi

Dan Dou Chi

Fermented soybean

Dosage 9g
Temperature Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach
Preparation Wrap in cloth when decocting (绵裹)

Role in Shi Gao Tang

Assists Ma Huang in releasing the exterior and dispersing pathogenic factors outward through mild sweating. It also clears mild Heat from the chest and relieves restlessness and irritability, complementing both the exterior-releasing and interior-clearing strategies.
Assistants — Supports or moderates other herbs
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Shi Gao Tang

Clears Heat from the Upper Burner, particularly the Lungs and Heart. Together with Huang Lian, Huang Bai, and Zhi Zi, it forms the core of the interior heat-clearing strategy (mirroring Huang Lian Jie Du Tang), draining Fire and resolving toxicity from all three Burners.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Shi Gao Tang

Clears Heat from the Middle Burner and drains Stomach Fire. Its bitter, cold nature strongly purges interior toxic Heat, addressing the delirium, mental confusion, and high fever that come from intense interior Heat accumulation.
Huang Qi

Huang Qi

Astragalus root

Dosage 6g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Shi Gao Tang

Clears Heat from the Lower Burner, particularly draining Kidney Fire. Completes the three-Burner heat-clearing strategy alongside Huang Qin and Huang Lian, ensuring toxic Heat is addressed throughout the entire body.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Preparation Break open before decocting (擘)

Role in Shi Gao Tang

Drains Heat and Fire across all three Burners, clearing Heat through the urine as a downward-draining route. Also clears Heart Heat to relieve irritability and restlessness. Works synergistically with the three Huang herbs to comprehensively purge interior Fire-toxin.

Why This Combination Works

How the herbs in Shi Gao Tang complement each other

Overall strategy

Shi Gao Tang addresses a dangerous clinical situation where an external pathogen remains trapped at the surface while intense Heat rages internally. Neither purely releasing the exterior (which would worsen the interior toxin) nor purely clearing the interior (which would leave the exterior pathogen unresolved) will work alone. The formula therefore employs a dual strategy: simultaneously releasing the exterior through sweating and clearing interior Heat through bitter-cold Fire-draining herbs.

King herbs

Shi Gao (Gypsum) serves as King at the highest dose (30g). Its sweet, acrid, and very cold nature directly targets the Yangming Stomach channel to powerfully drain internal Fire, clear Heat, and relieve the intense restlessness and thirst. Because Shi Gao also has a mild muscle-layer releasing action, it bridges the gap between exterior and interior treatment, making it the ideal King for this dual-action formula.

Deputy herbs

Ma Huang (Ephedra) and Dan Dou Chi (Fermented Soybean) form the exterior-releasing pair. Ma Huang opens the pores and induces sweating to expel the trapped surface pathogen, addressing the absence of sweating, body heaviness, and muscular stiffness. Dan Dou Chi gently assists this dispersing action while also alleviating chest stuffiness and irritability. Their combined action ensures the exterior pathogen can be expelled outward without being driven deeper.

Assistant herbs

Huang Qin, Huang Lian, Huang Bai, and Zhi Zi form a powerful interior heat-clearing team that mirrors the famous Huang Lian Jie Du Tang (Coptis Decoction to Resolve Toxicity). Each targets a different level of the body: Huang Qin clears the Upper Burner (Lungs and Heart), Huang Lian clears the Middle Burner (Stomach), and Huang Bai clears the Lower Burner (Kidneys). Zhi Zi drains Fire across all three Burners and directs Heat downward through the urine. Together they act as reinforcing Assistants, comprehensively purging toxic Heat from the interior to resolve delirium, high fever, and mental confusion.

Notable synergies

The Shi Gao and Ma Huang pairing is the formula's most distinctive feature: Ma Huang's warm, dispersing nature opens the exterior, while Shi Gao's cold, heavy nature prevents Ma Huang from worsening interior Heat. This creates a synergy where the exterior is released without fueling the internal Fire. The four bitter-cold herbs (the three Huang herbs plus Zhi Zi) work as a unit to drain Fire from all levels, while the exterior-releasing herbs (Ma Huang and Dan Dou Chi) prevent these cold, descending herbs from trapping the surface pathogen inside.

How to Prepare

Traditional preparation instructions for Shi Gao Tang

Chop all seven ingredients. Add approximately 2 litres (2000 ml) of water and decoct until reduced to about 600 ml. Strain and divide into three doses, taken warm throughout the day.

After the first dose, a mild sweat should appear. If symptoms persist, prepare a second batch and divide it across two days. The goal is to maintain a light, continuous perspiration until the muscle stiffness, restlessness, and mental cloudiness resolve. If the patient experiences several episodes of loose stool, this indicates the internal toxic Heat is breaking and the formula is taking effect.

Shi Gao (Gypsum) should be crushed and decocted first for 20 to 30 minutes before adding the remaining herbs.

Common Modifications

How practitioners adapt Shi Gao Tang for specific situations

Added
Da Huang

6-9g, to purge accumulated Heat through the bowels

When Heat has accumulated in the intestines causing constipation, Da Huang's downward-draining and purgative action provides an additional route to expel the pathogenic Heat, complementing the formula's existing clearing strategy.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Gao Tang should not be used or requires extra caution

Avoid

Absence of sweating due to Body Fluids Deficiency rather than Exterior constraint. This formula is very drying and cold, and would further deplete fluids in a Yin-deficient patient.

Caution

Purely Interior Heat with no remaining Exterior pattern. If there is no Exterior involvement, formulas such as Huang Lian Jie Du Tang alone are more appropriate.

Avoid

Spleen and Stomach Yang Deficiency or Cold patterns. The formula is intensely cold and bitter, and would severely damage digestive function in those with underlying cold or deficiency.

Avoid

Pregnancy. Ma Huang promotes sweating and circulates Qi strongly; Zhi Zi, Huang Lian, Huang Bai, and Huang Qin are all intensely cold and bitter, which may be harmful in pregnancy.

Caution

Mild or early-stage febrile disease where the illness has not yet penetrated the Interior. This formula is designed for severe combined Exterior-Interior Heat and is too aggressive for ordinary colds or surface-level illness.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. Ma Huang (Ephedra) is a strong diaphoretic that promotes sweating and circulates Qi vigorously, which could stimulate uterine activity. The formula also contains four intensely cold and bitter herbs (Huang Qin, Huang Lian, Huang Bai, Zhi Zi) that collectively exert a powerful downward-draining and cold action, which poses a risk to fetal stability. This formula is designed for acute, severe febrile emergencies and is not appropriate for pregnant patients under any circumstances.

Breastfeeding

Use with significant caution during breastfeeding. Ma Huang (Ephedra) contains ephedrine alkaloids that are known to pass into breast milk and may cause irritability, poor sleep, or reduced feeding in the nursing infant. Huang Lian (Coptis) contains berberine, which is bitter and cold and could potentially affect the infant through breast milk, though data is limited. The formula's overall extremely cold and bitter nature may also reduce milk production by damaging Spleen and Stomach Qi, which TCM considers the source of milk generation. This formula should only be used during breastfeeding in genuine emergencies of severe febrile illness, and for the shortest possible duration.

Children

This formula may be used in children for severe febrile conditions with combined Exterior and Interior Heat, but requires significant dosage reduction. A general guideline is to reduce adult doses by 50-75% depending on the child's age and weight. Ma Huang (Ephedra) must be used with particular caution in young children, as its stimulant properties can affect heart rate and sleep. The intensely cold and bitter nature of the four clearing herbs (Huang Qin, Huang Lian, Huang Bai, Zhi Zi) can easily damage a child's immature digestive system, so treatment duration should be kept short and the child monitored closely for diarrhea or loss of appetite. This formula should only be administered to children under professional supervision for genuinely severe febrile emergencies, not for mild childhood fevers.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Gao Tang

Ma Huang (Ephedra) interactions: Ma Huang contains ephedrine and pseudoephedrine, which are sympathomimetic agents. It may interact dangerously with MAO inhibitors (risk of hypertensive crisis), stimulant medications, decongestants, caffeine, cardiac glycosides (digoxin), and beta-blockers. It may also interfere with antihypertensive medications by raising blood pressure and heart rate. Concurrent use with anaesthetics should be avoided.

Huang Lian (Coptis) interactions: Huang Lian contains berberine, which has documented interactions with several drug classes. Berberine may increase the blood levels of cyclosporine and other drugs metabolized by CYP3A4. It may enhance the effects of hypoglycaemic agents (metformin, sulfonylureas), potentially causing excessive blood sugar lowering. Berberine may also interact with anticoagulants and antiplatelet drugs.

Huang Qin (Scutellaria) interactions: Baicalin and baicalein in Huang Qin may affect drug metabolism through CYP enzymes and may interact with anticoagulant medications.

Zhi Zi (Gardenia) interactions: Geniposide in Zhi Zi is hepatically metabolized and may interact with drugs processed through the liver, though clinical data is limited. Patients taking hepatotoxic medications should exercise caution.

Usage Guidance

Practical advice for getting the most out of Shi Gao Tang

Best time to take

Three times daily, taken warm. The classical instructions note that the first dose should produce mild sweating; subsequent doses are divided across the following days.

Typical duration

Acute use only: 1–3 days, with reassessment after each dose. The formula instructions specify beginning with one dose to induce mild sweating, then a second dose split over two days.

Dietary advice

While taking this formula, avoid greasy, rich, and fried foods, as these generate internal Heat and Dampness that work against the formula's purpose. Avoid warming or spicy foods such as lamb, chili, ginger, garlic, and alcohol, which would add Fire to an already Heat-dominant condition. Favour light, easily digestible foods such as plain rice porridge (congee), mung bean soup, and fresh vegetables. Stay well hydrated, as the formula promotes sweating and the underlying condition involves significant fluid loss. Cold or raw foods in small amounts are acceptable given the Heat pattern, but avoid excessive cold foods if diarrhea develops from the formula's bitter-cold nature.

Shi Gao Tang originates from Wài Tái Bì Yào (外台秘要), citing Shēn Shī Fāng (深师方) Táng dynasty, 752 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Gao Tang and its clinical use

《外台秘要》引《深师方》(Wài Tái Mì Yào citing Shēn Shī Fāng):
"今直用解毒汤,则挛急不愈;直用汗药,则毒因加剧。而方无表里疗者,意思以三黄汤以救其内,有所增加以解其外,故名石膏汤。"
Translation: "If one uses only Jie Du Tang [Toxin-Resolving Decoction], the cramping and tension will not heal; if one uses only diaphoretic medicines, the toxin will worsen. Since there was no formula that treated both the Exterior and Interior, the idea was to use San Huang Tang [Three Yellow Decoction] to rescue the Interior, with additions to release the Exterior — hence the name Shi Gao Tang."

《医方集解》(Yī Fāng Jí Jiě) by Wang Ang:
"此足太阳、手少阳药也。表里之邪俱盛,欲治内则表不除,欲发表则里又急,故以黄芩泻上焦之火,黄连泻中焦之火,黄柏泻下焦之火,栀子通泻三焦之火,而以麻黄、淡豉发散表邪,石膏泻胃火,能解肌,亦表里分消之药也。"
Translation: "This is a formula of the Foot Taiyang and Hand Shaoyang channels. When pathogenic factors of both Exterior and Interior are strong — if one treats the Interior, the Exterior is not resolved; if one releases the Exterior, the Interior becomes more urgent — therefore Huang Qin drains Upper Burner Fire, Huang Lian drains Middle Burner Fire, Huang Bai drains Lower Burner Fire, Zhi Zi drains Fire from all Three Burners, while Ma Huang and Dan Dou Chi disperse Exterior pathogens, and Shi Gao drains Stomach Fire and can release the muscle layer. It is thus a formula that resolves both Exterior and Interior simultaneously."

Historical Context

How Shi Gao Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shi Gao Tang originates from the Shēn Shī Fāng (深师方), an early medical text that is no longer independently extant. It was preserved through its citation in the Wài Tái Mì Yào (外台秘要, Arcane Essentials from the Imperial Library), compiled by Wang Tao (王焘) in 752 CE during the Tang Dynasty. The formula represents an ingenious structural solution to the clinical problem of concurrent Exterior and Interior disease: it merges two existing treatment strategies into one. The Interior-clearing component is essentially Huang Lian Jie Du Tang (黄连解毒汤, Coptis Toxin-Resolving Decoction) — composed of Huang Qin, Huang Lian, Huang Bai, and Zhi Zi — a formula from the same era attributed to Wang Tao's compilation. The Exterior-releasing component adds Ma Huang and Dan Dou Chi (prepared soybean) to open the surface and promote sweating, while Shi Gao serves a dual role: clearing Stomach-level Heat internally while also helping to release the muscle layer externally.

Later, the Ming Dynasty physician Tao Hua (陶华) modified Shi Gao Tang by adding ginger, jujube, and fine tea, creating the well-known San Huang Shi Gao Tang (三黄石膏汤, Three Yellow Gypsum Decoction), recorded in his Shāng Hán Liù Shū (伤寒六书). This modification became one of the more commonly cited versions in later clinical practice. Wang Ang's Yī Fāng Jí Jiě (医方集解) provided an influential theoretical analysis of the formula, mapping its action to the Foot Taiyang and Hand Shaoyang channels and explaining how each herb addresses a specific layer of the Three Burners.