Formula Pill (Wan)

Gu Jing Wan

Stabilize the Menses Pill · 固經丸

Also known as: 樗白固经丸 (Chū Bái Gù Jīng Wán), Stabilize Menstruation Pill

A classical formula used to address heavy or prolonged menstrual bleeding caused by internal heat and weakened Yin (the body's cooling, nourishing aspect). It works by replenishing Yin, clearing excess heat from the blood, and helping stabilize the menstrual cycle. It is especially suited for women experiencing dark, thick menstrual blood with warmth in the palms and soles.

Origin 丹溪心法 (Dān Xī Xīn Fǎ, Essential Teachings of Zhu Danxi) — Yuán dynasty, ~1347 CE
Composition 6 herbs
Gui Ban
King
Gui Ban
Bai Shao
King
Bai Shao
Huang Qin
Deputy
Huang Qin
Huang Qi
Deputy
Huang Qi
Chun Pi
Assistant
Chun Pi
Xiang Fu
Assistant
Xiang Fu
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gu Jing Wan is designed to correct these specific patterns.

Why Gu Jing Wan addresses this pattern

When Liver and Kidney Yin become depleted, deficiency-Fire arises internally. This Heat enters the Blood level and destabilizes the Chong (Penetrating) and Ren (Conception) vessels, the two extraordinary vessels that govern menstruation. The result is Blood being forced out of the vessels prematurely and excessively. Gu Jing Wan addresses this by using Gui Ban and Bai Shao to replenish the depleted Yin at its root in the Liver and Kidney, while Huang Qin and Huang Bai clear the pathological Heat that is driving the reckless bleeding. Chun Gen Pi directly astringes to stop the flow, and Xiang Fu keeps the Qi moving to prevent the cold, astringent herbs from trapping stasis.

A practitioner would look for one or more of these signs

Excessive Menstruation

Heavy menstrual flow, or alternating between flooding and spotting

Bleeding

Bleeding that may be prolonged or continuous (崩漏)

Dark Menstrual Blood

Blood that is deep red, purplish-black, thick, or clotted

Sensation Of Heat In The Palms

Heat sensation in palms, soles, and chest (five-palm heat)

Sore

Aching and weakness in the lower back and knees

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gu Jing Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Yin Deficiency Blood Heat

TCM Interpretation

In TCM, dysfunctional uterine bleeding (called 崩漏, bēng lòu) is understood as a failure of the Chong and Ren extraordinary vessels to contain and regulate Blood flow. When Liver and Kidney Yin become depleted, whether through overwork, chronic illness, emotional strain, or aging, the cooling and anchoring function they provide weakens. Without enough Yin to counterbalance Yang, deficiency-Fire develops and agitates the Blood, forcing it out of the vessels. The flooding type (崩, bēng) represents a sudden, heavy loss, while the spotting type (漏, lòu) is a persistent, low-grade leak. Both reflect the same underlying problem of Yin failing to hold Blood in place.

Why Gu Jing Wan Helps

Gu Jing Wan attacks this problem on multiple fronts. Gui Ban replenishes Kidney Yin and subdues the rising deficiency-Fire at its source. Bai Shao nourishes Liver Blood and uses its sour, astringent nature to help contain the Blood. Huang Qin and Huang Bai clear the Heat that is actively pushing Blood out of the vessels, working at the upper and lower body respectively. Chun Gen Pi provides a direct astringent action on the uterus to physically help stop the bleeding. The small addition of Xiang Fu ensures the formula does not simply freeze everything in place, which could trap old Blood and create stagnation.

Also commonly used for

Irregular Menstruation

Menstrual periods that come early or are prolonged

Excessive Vaginal Discharge

Abnormal vaginal discharge (赤白带下)

Metrorrhagia

Uterine bleeding between periods

Pelvic Inflammatory Disease

Chronic pelvic inflammatory disease with bleeding

Gastrointestinal Bleeding

When pattern matches Yin deficiency with Blood Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gu Jing Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gu Jing Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gu Jing Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gu Jing Wan works at the root level.

The condition Gu Jing Wan addresses begins with Yin deficiency of the Liver and Kidneys. In TCM, the Kidneys store Essence and the Liver stores Blood, and both organs are deeply connected to the Chong and Ren vessels, the two extraordinary channels that govern menstruation and the uterus. When Liver and Kidney Yin becomes depleted, it loses the ability to anchor and cool the body's Yang and ministerial Fire (相火). This unchecked Fire, which TCM calls 'deficiency Heat,' flares up and disturbs the Chong and Ren vessels, forcing Blood out of its normal pathways.

The classical Su Wen states "when Yin is deficient and Yang surges, this is called flooding" (阴虚阳搏谓之崩). In practical terms, the patient experiences heavy, prolonged menstrual bleeding or irregular uterine bleeding (崩漏, alternating between heavy gushing and persistent trickling). The blood is characteristically dark red or purplish-black and thick, because intense Heat concentrates and darkens the Blood. Accompanying signs include heat in the palms and soles, soreness and weakness of the lower back and knees (reflecting Kidney Yin depletion), a red tongue, and a wiry, rapid pulse, all pointing to Yin deficiency with internal Heat.

Gu Jing Wan works by addressing both the root and the branch simultaneously. It replenishes Liver and Kidney Yin (the root cause) while clearing the deficiency Heat that is driving Blood out of the vessels (the immediate trigger). At the same time, an astringent herb is included to directly check the bleeding. A small amount of Qi-regulating herb ensures that the cooling, astringent approach does not inadvertently cause Blood stasis. This multi-layered strategy restores the balance between Yin and Fire so that the Chong and Ren vessels regain their stability and Blood is held within its proper channels.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and salty with mild sourness. Bitter to clear Heat and dry, salty to nourish Yin and anchor Yang, sour to astringe and stop bleeding.

Channels Entered

Liver Kidney

Ingredients

6 herbs

The herbs that make up Gu Jing Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Gui Ban

Gui Ban

Tortoise plastron

Dosage 15 - 30g
Temperature Cold
Taste Salty (咸 xián), Sweet (甘 gān)
Organ Affinity Liver, Heart, Kidneys
Preparation Dry-fried (炙); decocted first for 20-30 minutes when used in decoction form

Role in Gu Jing Wan

Nourishes Kidney Yin, subdues rising Yang, and restrains overactive Fire. As one of the primary Yin-nourishing substances, it addresses the root cause of the pattern by replenishing the depleted Yin of the Liver and Kidney.
Bai Shao

Bai Shao

White peony root

Dosage 15 - 30g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Preparation Stir-fried (炒)

Role in Gu Jing Wan

Restrains and preserves Yin, nourishes the Blood, and softens the Liver. Its sour-astringent nature helps consolidate Yin and Blood, while nourishing the Liver to address the Liver-Kidney axis deficiency that underlies the bleeding.
Deputies — Assists and enhances the King
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 15 - 30g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Preparation Stir-fried (炒)

Role in Gu Jing Wan

Clears Heat from the upper and middle burners, cools the Blood, and stops bleeding. Its bitter-cold nature directly addresses the Heat that is driving blood out of the vessels. Used at a high dose (equal to the Kings) to emphasize its heat-clearing role.
Huang Qi

Huang Qi

Astragalus root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Preparation Stir-fried (炒)

Role in Gu Jing Wan

Drains Fire from the lower burner and strengthens Yin. It complements Huang Qin by targeting the lower body where the reproductive organs reside, specifically clearing the deficiency-Fire that is destabilizing the Chong and Ren vessels.
Assistants — Supports or moderates other herbs
Chun Pi

Chun Pi

Ailanthus bark

Dosage 12 - 22.5g
Temperature Cold
Taste Bitter (苦 kǔ), Astringent (涩 sè)
Organ Affinity Large Intestine, Liver, Stomach

Role in Gu Jing Wan

Bitter, astringent, and cool, it directly binds and stops bleeding while also securing the menses. This is the formula's key astringent herb, adding a physical 'holding' action to the Yin-nourishing and heat-clearing strategy.
Xiang Fu

Xiang Fu

Nutgrass rhizome

Dosage 6 - 7.5g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)

Role in Gu Jing Wan

Moves Qi and regulates menstruation. Used in a small dose to prevent the formula's predominantly cold and astringent herbs from causing Qi stagnation or trapping residual Blood stasis. Ensures that stopping the bleeding does not create new problems by congealing the Blood.

Why This Combination Works

How the herbs in Gu Jing Wan complement each other

Overall strategy

The core problem is Yin deficiency generating internal Heat that destabilizes the Chong and Ren vessels, forcing Blood to move recklessly. The formula therefore uses a two-pronged approach: replenishing Yin to address the root, while simultaneously clearing Heat and astringing Blood to manage the symptoms.

King herbs

Gui Ban (Tortoise Plastron) and Bai Shao (White Peony Root) share the King role. Gui Ban is salty-sweet and cool, entering the Kidney and Liver channels to nourish Yin at its source and subdue rising deficiency-Fire. Bai Shao is sour-bitter and cool, preserving Yin and nourishing Liver Blood. Together they address the root deficiency in both the Liver and Kidney, restoring the Yin foundation that should keep Blood securely within the vessels.

Deputy herbs

Huang Qin and Huang Bai reinforce the Kings by directly clearing the pathological Heat. Huang Qin clears Heat from the upper and middle portions of the body and is particularly effective at cooling Blood to stop bleeding. Huang Bai focuses on the lower burner, draining deficiency-Fire from the Kidney domain and strengthening Yin. Together they attack Heat at both the upper and lower levels.

Assistant herbs

Chun Gen Pi (Ailanthus Root Bark) serves as a reinforcing assistant with its bitter, astringent, and cool nature, directly binding the menses and stopping excessive bleeding. This gives the formula an immediate symptomatic effect while the King and Deputy herbs work on the deeper imbalance. Xiang Fu serves as a restraining assistant: its warm, Qi-moving nature prevents the formula's heavy cold and astringent composition from stagnating Qi or trapping Blood stasis. By keeping Qi flowing smoothly, it ensures the bleeding stops cleanly without creating clots or new stagnation.

Notable synergies

The Gui Ban and Bai Shao pairing is a classical Yin-nourishing combination that works across the Liver-Kidney axis. The Huang Qin and Huang Bai pairing clears Heat at two levels (upper/middle and lower burner). The small dose of Xiang Fu balancing against the larger mass of cold-astringent herbs embodies the formula's hallmark design principle, described as "astringent without causing stagnation" (涩而不滞).

How to Prepare

Traditional preparation instructions for Gu Jing Wan

Grind all six herbs into a fine powder. Mix with wine-paste (酒糊) to form pills the size of Chinese parasol tree seeds (about 6mm diameter). Take approximately 50 pills (about 6g) per dose on an empty stomach, swallowed with warm wine or plain warm water, twice daily.

In modern clinical practice, this formula may also be prepared as a water decoction. When used as a decoction, combine the herbs in appropriate proportions, add water, and decoct as usual. Pre-made pill and granule forms are also commercially available.

Common Modifications

How practitioners adapt Gu Jing Wan for specific situations

Added
Shu Di Huang

15-30g, to strengthen Yin nourishment and cool the Blood

E Jiao

9-12g (dissolved separately), to nourish Blood and stop bleeding

Sheng Di Huang strongly cools Blood and nourishes Yin to reinforce the core strategy, while E Jiao nourishes and astringes Blood directly, providing an additional hemostatic layer for severe cases.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gu Jing Wan should not be used or requires extra caution

Avoid

Uterine bleeding caused by Blood stasis. The formula's cooling and astringent nature could worsen stasis by trapping stagnant Blood, leading to the classical concern of 'bitter cold retaining stasis' (苦寒留瘀).

Avoid

Spleen and Stomach deficiency Cold with symptoms such as poor appetite, loose stools, cold limbs, and aversion to cold. The formula's predominantly cold and bitter herbs will further injure the Spleen Yang.

Avoid

Uterine bleeding due to Spleen Qi deficiency failing to hold Blood (Qi not controlling Blood). This pattern requires Qi-tonifying and Blood-securing treatment, not Yin-nourishing and Heat-clearing. Gu Chong Tang would be more appropriate.

Avoid

Excessive menstrual bleeding caused by Yang deficiency Cold. This formula would worsen the underlying Cold and could aggravate the bleeding.

Caution

Prolonged use in patients without clear signs of Yin deficiency Heat. The cold, bitter nature of the formula can gradually damage Spleen and Stomach function if used unnecessarily.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Huang Bai (Phellodendron bark) and Huang Qin (Scutellaria) are cold and bitter herbs that, in large doses, may theoretically affect the fetus, although Huang Qin is traditionally considered safe and even used to calm the fetus in some formulas. Chun Gen Pi (Ailanthus bark) is astringent and cooling and has limited safety data in pregnancy. The formula was designed for non-pregnant women with menstrual disorders, and its Yin-nourishing, Heat-clearing approach is not typically indicated during pregnancy. Pregnant women should consult a qualified practitioner before use.

Breastfeeding

The formula contains Huang Bai (Phellodendron) and Huang Qin (Scutellaria), both very bitter and cold herbs. Berberine from Huang Bai and baicalin from Huang Qin may transfer into breast milk. The bitter, cold nature of the formula could potentially affect the nursing infant's digestion, particularly in very young infants with immature digestive systems. Use during breastfeeding should be supervised by a qualified practitioner who can assess whether the benefits outweigh the risks and adjust dosage accordingly.

Children

Gu Jing Wan is a gynecological formula designed for adult women with menstrual disorders caused by Yin deficiency Heat. It is not a standard pediatric formula. In adolescent girls who have reached menarche and present with clear signs of Yin deficiency Heat-type menorrhagia, a practitioner may consider using a reduced dose (typically one-third to one-half the adult dose), but only under professional supervision. The cold, bitter nature of the formula makes it unsuitable for young children and for adolescents with immature or weak digestive function.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gu Jing Wan

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Huang Qin (Scutellaria) contains baicalin and baicalein, which have demonstrated antiplatelet and anti-inflammatory effects in pharmacological studies. Concurrent use with anticoagulants may theoretically increase bleeding risk, which is particularly concerning given that the formula is already used for bleeding conditions.

Antihypertensive medications: Huang Bai (Phellodendron) contains berberine, which has been shown to lower blood pressure and blood glucose in some studies. Patients on antihypertensive drugs should be monitored for additive hypotensive effects.

Hypoglycemic drugs (e.g. metformin, sulfonylureas): Berberine from Huang Bai has well-documented blood glucose-lowering properties. Combined use may potentiate the hypoglycemic effect, requiring blood sugar monitoring.

Cytochrome P450 substrates: Berberine is known to inhibit several CYP450 enzymes (particularly CYP2D6, CYP2C9, and CYP3A4). Patients taking medications metabolized by these enzymes should be aware of potential interactions that could alter drug levels.

Usage Guidance

Practical advice for getting the most out of Gu Jing Wan

Best time to take

On an empty stomach, traditionally with warm water or diluted warm rice wine (as per the original instructions). Typically taken twice daily, morning and evening, 30 minutes before meals.

Typical duration

Often taken for 2 to 4 weeks during active bleeding episodes, then reassessed. May be continued for 1 to 3 menstrual cycles to consolidate the effect, with regular practitioner review.

Dietary advice

Avoid spicy, hot, and pungent foods (chili, garlic, ginger, pepper, lamb, deep-fried foods) as these generate Heat and counteract the formula's cooling action. Avoid greasy and rich foods that burden the Spleen and generate Dampness. Avoid alcohol, which heats the Blood and can worsen bleeding. Favor cooling, Yin-nourishing foods such as pear, lotus root, lily bulb, wood ear mushroom, mung beans, and dark leafy greens. Moderate intake of Blood-nourishing foods like black sesame, goji berries, and beet is supportive.

Gu Jing Wan originates from 丹溪心法 (Dān Xī Xīn Fǎ, Essential Teachings of Zhu Danxi) Yuán dynasty, ~1347 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gu Jing Wan and its clinical use

《丹溪心法》卷五 (Dān Xī Xīn Fǎ, Volume 5):
Original indication: 「妇人经水过多。」
Translation: "For women with excessive menstrual flow."

《素问·阴阳别论》(Sù Wèn, Treatise on the Separation and Union of Yin and Yang):
「阴虚阳搏谓之崩。」
Translation: "When Yin is deficient and Yang surges, this is called flooding (uterine hemorrhage)." This classical principle from the Inner Canon is the theoretical foundation for the pattern that Gu Jing Wan treats.

《医方集解》(Yī Fāng Jí Jiě) by Wāng Áng:
「此足少阴、厥阴药也。经多不止者,阴虚不足以制胞络之火,故越其常度也;崩中漏下者,虚而挟热也;紫黑成块者,火极似水也。黄芩清上焦之火,黄柏泻下焦之火;龟版、芍药滋阴而养血,皆壮水以制阳光也;香附辛以散郁,樗皮涩以止脱。」
Translation: "This is a formula for the Kidney and Liver channels. Excessive menstrual bleeding that does not stop is because Yin deficiency is insufficient to restrain the Fire of the uterine vessels, causing the flow to exceed its normal measure. Flooding and trickling are due to deficiency with concurrent Heat. Dark purple clotted blood is because extreme Fire mimics Water. Huang Qin clears upper burner Fire; Huang Bai drains lower burner Fire. Tortoise plastron and Peony nourish Yin and Blood, all enriching Water to control Yang brilliance. Xiang Fu, with its acrid nature, disperses stagnation; Ailanthus bark, with its astringency, checks the leakage."

Historical Context

How Gu Jing Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gu Jing Wan originates from the work of Zhu Danxi (朱丹溪, 1281–1358), one of the four great physicians of the Jin-Yuan era and the founder of the 'Nourishing Yin' school of thought (滋阴学派). The formula first appeared in his influential text Dan Xi Xin Fa (丹溪心法, Volume 5), compiled by his students. Notably, the formula had no formal name in the original text. The name 'Gu Jing Wan' (Stabilize the Menses Pill) was later assigned when it was recorded in the Yi Fang Lei Ju (医方类聚, Volume 210) citing the Xin Xiao Fang (新效方). An alternative name, Chu Bai Gu Jing Wan (樗白固经丸), appears in the Jian Ming Yi Gu (简明医彀).

The formula is a direct expression of Zhu Danxi's core philosophical principle: "Yang is always in excess; Yin is always insufficient" (阳常有余,阴常不足). Where other physicians of his era might have treated uterine bleeding primarily with astringent or warming methods, Danxi identified Yin deficiency and Heat as the critical mechanism and designed a formula that prioritizes nourishing Yin and clearing Heat over simply stopping the bleeding. The Qing dynasty physician Wang Ang (汪昂) later provided a detailed analytical commentary in his Yi Fang Ji Jie (医方集解), classifying the formula as acting on the Kidney (foot Shaoyin) and Liver (foot Jueyin) channels. The Korean medical classic Donguibogam (东医宝鉴) also adopted the formula, noting a variant that substitutes Bai Zhu for Bai Shao.