Bi Xie Fen Qing Yin

Dioscorea Drink to Separate the Clear · 萆薢分清飲

Also known as: Bi Xie Fen Qing San (萆薢分清散) - original name, Fen Qing San (分清散), Fen Qing Yin (分清飲),

A classical formula used to support urinary health when there is cloudy or milky urine, frequent urination, and signs of cold in the lower body. It works by gently warming the Kidneys and Bladder to help the body properly separate clean fluids from waste, restoring normal urination.

Origin Yang Shi Jia Cang Fang (杨氏家藏方, Yang's Family Treasury of Formulas) — Southern Sòng dynasty, ~1178 CE
Composition 4 herbs
Bi Xie
King
Bi Xie
Yi Zhi Ren
Deputy
Yi Zhi Ren
Wu Yao
Assistant
Wu Yao
Shi Chang Pu
Assistant
Shi Chang Pu
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bi Xie Fen Qing Yin is designed to correct these specific patterns.

Why Bi Xie Fen Qing Yin addresses this pattern

When Kidney Yang is insufficient, it cannot adequately warm and drive the Qi transformation process in the lower body. The Bladder depends on Kidney Yang to properly open and close, and to separate clean fluids (which are recycled) from turbid waste (which is excreted as urine). When this warming function fails, turbid dampness accumulates and mixes with the urine, producing the hallmark milky or cloudy appearance. The Kidney also loses its ability to consolidate and hold, resulting in frequent urination.

Bi Xie Fen Qing Yin directly addresses this by combining the turbidity-separating action of Bi Xie and Shi Chang Pu with the Kidney-warming, essence-securing actions of Yi Zhi Ren and Wu Yao. The pinch of salt directs everything to the Kidney channel. This makes the formula particularly well-suited for Kidney Yang deficiency manifesting in the urinary system, as opposed to formulas that simply drain dampness without addressing the underlying cold.

A practitioner would look for one or more of these signs

Cloudy Urine

White and milky like rice water, or thick like paste

Frequent Urination

Frequent and uncontrolled, worse with cold

Cold Limbs

Cold sensation in lower back and extremities

Pale Tongue

Pale tongue with white coating

Eye Fatigue

General tiredness and weakness in the lower back and knees

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bi Xie Fen Qing Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic prostatitis with white or cloudy urethral discharge, urinary frequency, and a heavy sensation in the perineum is understood as turbid dampness accumulating in the lower body due to insufficient Kidney Yang. The Kidney governs the lower body's water metabolism and the Bladder's opening and closing function. When Kidney Yang is weak, Qi transformation falters, allowing damp turbidity to collect in the region around what TCM calls the 'Jing Room' (the reproductive and urinary tract area). This creates the characteristic white, cloudy discharge and sluggish, frequent urination. The cold constitution also means the body lacks the warmth to clear the stagnation on its own.

Why Bi Xie Fen Qing Yin Helps

Bi Xie Fen Qing Yin directly targets the turbid dampness responsible for the cloudy discharge through Bi Xie's unique ability to separate clean from turbid fluids. Shi Chang Pu aromatically penetrates and transforms the stubborn dampness lodged in the prostate region. Meanwhile, Yi Zhi Ren and Wu Yao warm the Kidney Yang and restore proper Qi transformation in the Bladder, addressing the root cause that allowed the condition to develop. Clinical studies have reported treatment response rates above 80% using this formula with modifications for chronic prostatitis, suggesting meaningful clinical benefit.

Also commonly used for

Benign Prostatic Hypertrophy

With urinary frequency and turbid urine

Urinary Tract Infection

Recurrent infections with cold-deficiency constitution

Chronic Pyelonephritis

Attributed to lower burner deficiency cold

Leukorrhea

Profuse white vaginal discharge from cold-dampness

Chronic Pelvic Inflammatory Disease

With lower body cold-dampness pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bi Xie Fen Qing Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bi Xie Fen Qing Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bi Xie Fen Qing Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bi Xie Fen Qing Yin works at the root level.

The core disease mechanism that Bi Xie Fen Qing Yin addresses is a failure of the body's lower urinary system to properly sort and separate clean from dirty fluids, rooted in a weakness of the Kidneys. In TCM, the Kidneys play a central role in governing water metabolism in the lower body. Through their warming, Yang-aspect function, the Kidneys provide the "fire" that drives the Bladder's ability to transform fluids, properly separating clean Qi (which is recycled upward) from turbid waste (which is excreted as urine). When Kidney Yang becomes insufficient, this sorting function breaks down.

Without adequate Kidney warmth, Cold accumulates in the lower burner. This internal Cold creates an environment where Dampness and turbidity are not properly cleared. The Bladder, which relies on the Kidney's warming power to "open and close" correctly, loses its regulatory control. The result is that urine becomes cloudy and milky (described classically as "white like rice water" or "thick like paste"), because clear and turbid substances are no longer being properly separated. Urination also becomes frequent because the Kidneys can no longer hold and restrain fluids effectively. The pale tongue, white tongue coating, and deep pulse all reflect the underlying Cold and deficiency in the lower body.

This is fundamentally a deficiency-Cold pattern, not a Heat pattern. The turbidity in the urine is not caused by infection or inflammation (as in Damp-Heat conditions), but by the failure of the body's warming, transformative function. The formula corrects this by restoring Kidney Yang warmth, re-establishing the Bladder's ability to sort fluids, and actively resolving the accumulated turbid Dampness that has already built up.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly bitter and acrid (pungent), with mild sweetness. Bitter to dry Dampness and resolve turbidity, acrid to warm and move Qi, mildly sweet to tonify the Kidneys.

Channels Entered

Kidney Bladder Liver Stomach

Ingredients

4 herbs

The herbs that make up Bi Xie Fen Qing Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Bi Xie

Bi Xie

Fish-poison yam rhizome

Dosage 9 - 12g
Temperature Neutral
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Stomach, Urinary Bladder

Role in Bi Xie Fen Qing Yin

The chief herb and namesake of the formula. Bi Xie excels at separating the clear from the turbid in the lower body, draining dampness downward and out through urination. It is the principal herb for treating cloudy urination (bai zhuo) and milky painful urination (gao lin), directly addressing the core pathomechanism of turbid dampness accumulating in the Bladder.
Deputy — Assists and enhances the King
Yi Zhi Ren

Yi Zhi Ren

Alpinia Fruit

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Kidneys

Role in Bi Xie Fen Qing Yin

Warms Kidney Yang, astringes essence, and reduces urinary frequency. By strengthening the Kidney's ability to hold and consolidate, it tackles the root cause of excessive and uncontrolled urination due to Kidney deficiency. It complements the King herb by addressing the underlying weakness while Bi Xie drains the pathogenic dampness.
Assistants — Supports or moderates other herbs
Wu Yao

Wu Yao

Lindera root

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Kidneys, Urinary Bladder

Role in Bi Xie Fen Qing Yin

Warms the Kidneys and disperses cold, moves Qi and relieves pain. It warms the Bladder to support Qi transformation, helping the body properly sort clean fluids from waste. Together with Yi Zhi Ren, it forms the core of Suo Quan Wan (Shut the Sluice Pill), a classical combination for frequent urination from Kidney Yang deficiency.
Shi Chang Pu

Shi Chang Pu

Acorus rhizome

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Stomach

Role in Bi Xie Fen Qing Yin

Aromatic, warm, and penetrating, Shi Chang Pu transforms turbid dampness and opens the waterways. It reinforces Bi Xie's ability to separate the clear from the turbid, while its warming nature helps expel cold-dampness from the Bladder. Its aromatic quality cuts through turbid congestion that the other herbs alone cannot fully resolve.

Why This Combination Works

How the herbs in Bi Xie Fen Qing Yin complement each other

Overall strategy

The formula addresses a lower body burdened by cold and dampness, where the Kidneys lack the warmth to properly sort clean fluids from waste. The strategy is twofold: drain the turbid dampness that has already accumulated, and warm the Kidney Yang so it stops forming in the first place.

King herb

Bi Xie (川萆薢) is the undisputed King and namesake of the formula. It has a special ability to separate clean fluids from turbid waste in the lower body and direct the turbid material out through urination. Classical texts regard it as the essential herb for cloudy urination and milky painful urination. It tackles the main symptom directly by resolving the accumulated turbid dampness in the Bladder.

Deputy herb

Yi Zhi Ren (益智仁) serves as Deputy by warming Kidney Yang and tightening the Kidney's holding function. While the King herb drains what is already turbid, Yi Zhi Ren addresses the root by strengthening the Kidney's capacity to consolidate essence and reduce excessive urination. This prevents the pattern from recurring once the acute turbidity clears.

Assistant herbs

Wu Yao (乌药) is a reinforcing Assistant that warms the Kidneys and Bladder, moves Qi, and disperses cold. It supports Qi transformation in the lower body so the Bladder can properly open and close. Together with Yi Zhi Ren, it recreates the classical pair found in Suo Quan Wan, a formula specifically designed for urinary frequency from cold deficiency. Shi Chang Pu (石菖蒲) is also a reinforcing Assistant. Its aromatic, warm nature cuts through turbid dampness and opens the waterways, amplifying Bi Xie's core action. It brings a penetrating quality that helps resolve stubborn turbidity that bland dampness-draining alone cannot clear.

Envoy herb

A small pinch of salt (食盐) is added during decoction as the Envoy. Salt is salty in taste and has a natural affinity for the Kidney channel. It guides the entire formula downward to the lower body where the pathology resides, ensuring the herbs reach their target.

Notable synergies

The pairing of Bi Xie with Shi Chang Pu creates a powerful turbidity-resolving combination: Bi Xie separates the clear from the turbid while Shi Chang Pu aromatically transforms the turbid dampness itself. The Yi Zhi Ren and Wu Yao pair (the core of Suo Quan Wan) provides the warming and consolidating foundation. The formula thus works on two levels simultaneously: draining and transforming the pathogenic dampness (Bi Xie + Shi Chang Pu) while warming and securing the deficient Kidneys (Yi Zhi Ren + Wu Yao).

How to Prepare

Traditional preparation instructions for Bi Xie Fen Qing Yin

The original method calls for grinding all four herbs in equal parts into a coarse powder. Take approximately 15g (about five qian) of the powder per dose, add a pinch of salt (roughly 0.5g), and decoct in one and a half cups of water. Simmer until reduced to about 70% of the original volume. Strain and take warm before meals.

In modern practice, the formula is commonly prepared as a standard decoction using whole herb pieces (yin pian) at standard dosages. Decoct all herbs together in approximately 400ml of water for 20 to 30 minutes. Add a small pinch of salt near the end of decoction. Take warm, twice daily, before meals.

Common Modifications

How practitioners adapt Bi Xie Fen Qing Yin for specific situations

Added
Rou Gui

3 - 6g, warms the interior and dispels cold

Xiao Hui Xiang

3 - 6g, warms the lower abdomen and alleviates pain

When cold in the lower body produces abdominal pain alongside cloudy urination, Rou Gui and Xiao Hui Xiang intensify the warming action to dispel cold from the interior and relieve pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bi Xie Fen Qing Yin should not be used or requires extra caution

Avoid

Damp-Heat patterns in the lower burner (Bladder Damp-Heat). When cloudy or painful urination is accompanied by yellow greasy tongue coating, yellow thick vaginal discharge, or signs of Heat, this warming formula is inappropriate. Formulas that clear Heat and drain Dampness (such as Ba Zheng San) should be used instead.

Avoid

Kidney Yin Deficiency. Because the formula is warming in nature and designed for Yang deficiency with Cold, using it in someone with Yin Deficiency (signs like night sweats, heat in palms and soles, dry mouth, red tongue with scanty coating) could further deplete Yin fluids.

Avoid

Excess Heat conditions. If the patient presents with true Heat signs such as high fever, strong thirst, red face, constipation, and a rapid forceful pulse, this formula's warming herbs would aggravate the condition.

Caution

Pregnancy. Yi Zhi Ren (Alpinia) and Wu Yao (Lindera) are warming and Qi-moving herbs. While not strongly contraindicated, their combined warming and Qi-moving actions warrant caution during pregnancy. Use only under qualified practitioner supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. The formula contains Wu Yao (Lindera root), which moves Qi and has mild warming, mobilizing properties, and Yi Zhi Ren (Alpinia fruit), which warms the Kidney. While neither herb is considered a strong abortifacient, the combined Qi-moving and warming actions in the lower burner could theoretically stimulate the uterus. There is no classical prohibition against use in pregnancy, but given the formula's focus on the lower burner, a qualified practitioner should assess the risk-benefit balance before prescribing to pregnant individuals.

Breastfeeding

No specific classical or modern contraindications for use during breastfeeding have been established. The herbs in this formula (Bi Xie, Yi Zhi Ren, Wu Yao, Shi Chang Pu) are generally considered mild and are not known to contain compounds that are toxic or harmful through breast milk transfer. However, the warming nature of the formula could theoretically affect milk quality in Heat-constitution mothers. Breastfeeding individuals should consult a qualified practitioner before use, and the infant should be monitored for any changes in feeding behavior or digestion.

Children

This formula can be used in children under practitioner guidance, with appropriate dosage reduction. General guidelines suggest reducing adult doses by approximately half for children aged 6-12, and by two-thirds for children under 6. The individual herbs are not considered toxic, and there are case reports of its use in pediatric enuresis (bedwetting). However, turbid urination in children should always be thoroughly evaluated to rule out underlying conditions such as urinary tract infections or metabolic disorders before using this formula. Taste may be an issue for very young children due to the bitter and aromatic flavor of the herbs.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bi Xie Fen Qing Yin

No major pharmacological drug interactions have been extensively documented for this specific four-herb formula. However, the following theoretical considerations apply:

  • Diuretic medications: Bi Xie (Dioscorea hypoglauca) has known diuretic properties. Concurrent use with pharmaceutical diuretics (thiazides, loop diuretics) could potentially enhance fluid loss and affect electrolyte balance. Monitoring is advisable.
  • Uric acid-lowering drugs (allopurinol, febuxostat): One small clinical study noted that combining BXFQY with febuxostat showed enhanced efficacy in improving renal function in hyperuricemic nephropathy patients. While this suggests a potentially beneficial interaction, close monitoring of uric acid levels and kidney function is recommended when combining the formula with these drugs.
  • Hypoglycemic agents: Dioscorea species contain steroidal saponins that may have mild effects on blood sugar metabolism. Patients on diabetes medications should monitor blood glucose levels.

Usage Guidance

Practical advice for getting the most out of Bi Xie Fen Qing Yin

Best time to take

Before meals (traditionally specified as 食前温服, 'taken warm before eating'), typically 30 minutes before meals, morning and evening.

Typical duration

Often taken for 2-4 weeks for acute episodes, then reassessed. For chronic conditions such as recurrent cloudy urination or chronic prostatitis, courses of 4-8 weeks with periodic reassessment are common.

Dietary advice

Avoid greasy, oily, and fried foods, which generate further Dampness and turbidity in the body. Reduce or eliminate alcohol consumption, as alcohol produces Damp-Heat. Limit cold and raw foods (including iced drinks, raw salads, and chilled fruit) that can further weaken Kidney Yang. Avoid strong tea and vinegar, which classical sources specifically caution against. Reduce high-purine foods (organ meats, shellfish, red meat) if the formula is being used for uric acid-related conditions. Favor warm, lightly cooked foods such as congee, cooked grains, warming soups, and mild spices like ginger to support the Spleen and Kidney Yang.

Bi Xie Fen Qing Yin originates from Yang Shi Jia Cang Fang (杨氏家藏方, Yang's Family Treasury of Formulas) Southern Sòng dynasty, ~1178 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bi Xie Fen Qing Yin and its clinical use

《杨氏家藏方》(Yang Shi Jia Cang Fang) — original source:
The formula was originally named 萆薢分清散 (Bi Xie Fen Qing San). It was prepared as a coarse powder, with each dose of approximately 9g decocted in water with a pinch of salt (食盐一捻) and taken before meals on an empty stomach (食前温服). This use of salt as an envoy herb was deliberate: saltiness (咸) enters the Kidney channel, guiding the formula's actions directly to the site of disease in the lower burner.

《丹溪心法》(Dan Xi Xin Fa) — Yuan Dynasty:
Zhu Danxi recorded the formula with the verse: 「萆薢分清石菖蒲,萆薢乌药益智俱,或益茯苓盐煎服,通心固肾浊精驱。」 ("Bi Xie Fen Qing [pairs with] Shi Chang Pu; Bi Xie, Wu Yao, and Yi Zhi Ren together; optionally add Fu Ling, decoct with salt; opens the Heart, secures the Kidneys, and drives out turbid essence.") This verse captures the formula's core strategy of warming the Kidneys and separating turbidity.

方解 (Formula analysis) — classical commentary:
「本方证为肾气不足,下焦虚寒,湿浊下注,肾失固摄所致。」 ("This formula's pattern arises from Kidney Qi insufficiency, deficiency Cold in the lower burner, Dampness and turbidity pouring downward, and the Kidneys losing their ability to contain and hold.") This passage concisely explains the entire pathomechanism that the formula addresses.

Historical Context

How Bi Xie Fen Qing Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Bi Xie Fen Qing Yin originated in the Southern Song Dynasty as Bi Xie Fen Qing San (萆薢分清散, "Bi Xie Powder to Separate the Clear"), first recorded in the Yang Shi Jia Cang Fang (杨氏家藏方, "Yang's Family Treasury of Formulas") by the physician Yang Tan (杨倓). The formula was structurally built upon the earlier Suo Quan Wan (缩泉丸, "Reduce the Spring Pill"), a two-herb combination of Yi Zhi Ren and Wu Yao used for frequent urination due to Bladder Qi deficiency. Yang Tan expanded this by adding Bi Xie for its turbidity-separating action and Shi Chang Pu for its aromatic Dampness-transforming properties, creating a more complete formula for cloudy, turbid urination.

During the Yuan Dynasty, the great physician Zhu Danxi (朱丹溪) included the formula in his influential Dan Xi Xin Fa (丹溪心法, "Teachings of Danxi"), renaming it from a "powder" (散) to a "decoction" (饮). This adoption by such a prominent figure helped establish the formula as a standard treatment for lower burner turbidity conditions. Later, in the Qing Dynasty, Cheng Guopeng (程国彭) created a distinct variant also called Bi Xie Fen Qing Yin in his Yi Xue Xin Wu (医学心悟, "Medical Insights"), but with a completely different composition including Huang Bai, Fu Ling, Bai Zhu, Lian Zi Xin, Dan Shen, and Che Qian Zi. This "Cheng's version" is cooling rather than warming, designed for Damp-Heat turbidity rather than deficiency Cold. The two versions are frequently distinguished in clinical practice: the original (Yang's) version for Cold-type turbidity, and Cheng's version for Heat-type turbidity.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Bi Xie Fen Qing Yin

1

Bi Xie Fen Qing Yin decoction alleviates potassium oxonate and adenine induced-hyperuricemic nephropathy in mice by modulating gut microbiota and intestinal metabolites (Preclinical study, 2024)

Lin X, Zou X, Hu B, Sheng D, Zhu T, Yin M, Xia H, Hu H, Liu H. Biomedicine & Pharmacotherapy, 2024, 170, 116bhm.

In a mouse model of hyperuricemic nephropathy, BXFQY significantly reduced plasma uric acid levels and improved kidney function. The formula suppressed NLRP3 inflammasome activation, reduced inflammatory and fibrosis markers in kidney tissue, protected intestinal barrier integrity, and favorably remodeled gut microbiota composition.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.